【摘要】：光學(xué)旋光法是一種無創(chuàng)血糖檢測技術(shù),通過測量眼前房水內(nèi)葡萄糖濃度來確定體內(nèi)血糖濃度水平。人眼運動引起的實時變化的雙折射是實現(xiàn)旋光法無創(chuàng)血糖測量的主要限制因素之一。設(shè)計了實時、閉環(huán)、雙調(diào)制多波長偏振系統(tǒng)來測量人工前房內(nèi)的葡萄糖濃度,人工前房由離體角膜固定在人工眼房上構(gòu)成。采用眼耦合裝置使光直線穿過眼前房從而避免了空氣與角膜之間折射率不匹配引起的光線彎曲。存在運動引起的雙折射時,采用雙波長旋光系統(tǒng)測量眼模型內(nèi)的葡萄糖濃度,兩次預(yù)測葡萄糖濃度的標準差分別為18.9mg/dL和15.2mg/dL,表明該系統(tǒng)具有降低活體角膜實變雙折射的潛力,有利于實現(xiàn)與血糖濃度相關(guān)的眼前房水內(nèi)葡萄糖濃度的精確測量。
[Abstract]:Optical rotation is a non-invasive blood glucose detection technique. Glucose concentration in aqueous humor can be determined by measuring glucose concentration in aqueous humor. Birefringence of real-time changes caused by human eye movement is one of the main limiting factors for noninvasive measurement of blood glucose by optical rotation. A real-time, closed-loop, dual-modulation multi-wavelength polarization system was designed to measure glucose concentration in the artificial anterior chamber, which was composed of an isolated cornea fixed on the artificial chamber. The eye coupling device is used to make the light straight through the anterior chamber so as to avoid the bending of light caused by the refractive index mismatch between the air and the cornea. In the presence of birefringence caused by motion, the glucose concentration in the eye model was measured by dual-wavelength optical rotation system. The standard deviation for the twice prediction of glucose concentration was 18.9mg/dL and 15.2mg / kg 路dL, respectively. It is suggested that the system has the potential to reduce birefringence of corneal consolidation in vivo, which is beneficial to the accurate measurement of glucose concentration in aqueous humor related to blood glucose concentration.
【作者單位】： 電子科技大學(xué)光電信息學(xué)院;德克薩斯州農(nóng)工大學(xué)生物醫(yī)學(xué)工程學(xué)院光學(xué)生物傳感實驗室;
【分類號】：O439;R446.1

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