【摘要】：目的了解臨床分離的黏質(zhì)沙雷菌臨床分布及耐藥情況,為臨床合理使用抗菌藥物、預(yù)防和控制感染提供依據(jù)。方法對(duì)某院2012年1月1日—2015年12月31日臨床分離的427株黏質(zhì)沙雷菌進(jìn)行分析,采用紙片擴(kuò)散法檢測(cè)其對(duì)常用抗菌藥物的敏感性。結(jié)果 427株黏質(zhì)沙雷菌標(biāo)本來(lái)源以呼吸道為主(70.26%),主要為痰(64.87%);科室分布主要為重癥監(jiān)護(hù)病房(ICU,19.44%),其次為中西醫(yī)結(jié)合科(15.46%)和康復(fù)科(13.58%)。黏質(zhì)沙雷菌對(duì)頭孢哌酮/舒巴坦、厄他培南、頭孢吡肟、頭孢他啶、阿米卡星、亞胺培南、左氧氟沙星和哌拉西林/他唑巴坦的耐藥率均10%;對(duì)環(huán)丙沙星、慶大霉素、妥布霉素、頭孢曲松、復(fù)方磺胺甲口惡唑和氨曲南的耐藥率為10%~30%。4年間耐藥率變化有統(tǒng)計(jì)學(xué)意義(P0.05)的有頭孢哌酮/舒巴坦、環(huán)丙沙星、頭孢曲松、阿米卡星、氨曲南和復(fù)方磺胺甲口惡唑;2012—2013年黏質(zhì)沙雷菌對(duì)頭孢哌酮/舒巴坦、環(huán)丙沙星、頭孢曲松、氨曲南和復(fù)方磺胺甲口惡唑耐藥率明顯增加,之后耐藥率趨于平穩(wěn);對(duì)頭孢哌酮/舒巴坦則耐藥性降低。結(jié)論黏質(zhì)沙雷菌對(duì)大部分常用抗菌藥物的敏感性較好,但耐藥性有增加的趨勢(shì);其中厄他培南、頭孢他啶、左氧氟沙星和哌拉西林/他唑巴坦敏感率高,可作為臨床治療相關(guān)感染的經(jīng)驗(yàn)用藥。
[Abstract]:Objective to investigate the clinical distribution and drug resistance of clinical isolates of Mycobacterium Shareh so as to provide evidence for rational use of antimicrobial agents and prevention and control of infection. Methods 427 strains of Mycobacterium Shareh isolated from a hospital from January 1, 2012 to December 31, 2015 were analyzed. The susceptibility to common antimicrobial agents was detected by disk diffusion method. Results 427 strains of M. Shareh were mainly from respiratory tract (70.26%) and sputum (64.87%). The distribution of departments was mainly in intensive care unit (ICU,19.44%), followed by integrated Chinese and western medicine (15.46%) and rehabilitation (13.58%). The resistance rates of M. Shareh to cefoperazone / sulbactam, etapenem, cefepime, ceftazidime, amikacin, imipenem, levofloxacin and piperacillin / tazobactam were all 10. The resistance rates of ciprofloxacin, gentamycin, tobramycin, ceftriaxone, compound sulfamethoxazole and aztreonam in ciprofloxacin, gentamycin, tobramycin, cefoperazone / sulbactam were significantly different (P0.05), and the resistance rates of ciprofloxacin, gentamycin, tobramycin, cefoperazone / sulbactam were significantly different (P0.05). Keywords ciprofloxacin, ceftriaxone, amikacin, aztreonam and compound sulfamethoxazole; In 2012-2013, the resistance rate of M. Shareh to cefoperazone / sulbactam, ciprofloxacin, ceftriaxone, aztreonam and compound sulfamethoxazole increased significantly, and the resistance rate to cefoperazone / sulbactam decreased. Conclusion the sensitivity of most commonly used antimicrobial agents is good, but the drug resistance tends to increase. Among them, ertapenem, ceftazidime, levofloxacin and piperacillin / tazobactam have high sensitivity.
【作者單位】： 中南大學(xué)湘雅醫(yī)院;
【基金】：[基金項(xiàng)目]湖南省教育廳湘教通(2012)594號(hào)
【分類號(hào)】：R446.5

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