【摘要】：目的探討血清胱抑素C對膿毒血癥患者心力衰竭發(fā)生的影響及相關因素,為臨床診治提供參考。方法選擇2014年2月-2016年2月膿毒血癥患者136例,其中47例伴發(fā)急性心力衰竭,比較不同患者血清胱抑素C水平的差異,并將左室射血分數(shù)(LVEF)、左心室舒張末內徑(LVDd)、E/e'等指標與胱抑素C水平進行相關分析。結果與單純膿毒血癥患者相比,伴發(fā)急性心力衰竭的患者血清胱抑素C的濃度更高(1.84±0.45mg/L vs1.15±0.27mg/L),差異有統(tǒng)計學意義(P0.05);胱抑素C的水平與年齡、LVEF、LVDd、E/e'等之間存在顯著的相關性(P均0.05);血清胱抑素C濃度≥1.58mg/L者發(fā)生急性心力衰竭的風險是濃度1.58 mg/L者的1.68倍,而且發(fā)生LVEF≤40%、LVDd≥60mm、E/e'≥17發(fā)生的風險也增高。結論伴發(fā)心力衰竭的膿毒血癥患者血清胱抑素C水平明顯增高,且升高的比例與發(fā)生急性心力衰竭的風險、異常心臟功能指標呈正相關,提示胱抑素C可作為臨床早期識別膿毒血癥患者發(fā)生急性心力衰竭的生物學指標。
[Abstract]:Objective to investigate the effect of serum cystatin C on the occurrence of heart failure in patients with sepsis and to provide reference for clinical diagnosis and treatment. Methods 136 patients with sepsis from February 2014 to February 2016 were selected, 47 of whom were associated with acute heart failure. The serum cystatin C levels in different patients were compared. Left ventricular ejection fraction (LVEF),) and left ventricular end-diastolic diameter (LVDd),) were compared. The correlation between E / E 'and cystatin C levels was analyzed. Results the concentration of cystatin C in patients with acute heart failure was significantly higher than that in patients with simple sepsis (1.84 鹵0.45mg/L vs1.15 鹵0.27mg/L) (P0.05). There was a significant correlation between the level of cystatin C and age, LVEF,LVDd,E/e', etc. The risk of acute heart failure in patients with serum cystatin C 鈮，

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