“以痛鎮(zhèn)痛”:條件性疼痛調(diào)節(jié)
發(fā)布時(shí)間：2018-08-19 06:41
【摘要】：條件性疼痛調(diào)節(jié)(CPM)是一種內(nèi)源性疼痛調(diào)節(jié),指身體某一部位的持續(xù)性疼痛可以抑制施于身體另一部位的傷害性刺激所引起的疼痛感知.本文首先概述了與CPM相關(guān)的神經(jīng)生理、生化機(jī)制,并介紹了測(cè)量個(gè)體CPM效率的傳統(tǒng)心理物理學(xué)方法,總結(jié)了基于腦電和功能磁共振等神經(jīng)成像技術(shù)評(píng)估CPM效率的神經(jīng)生理指標(biāo),并提出應(yīng)綜合心理物理學(xué)和神經(jīng)生理學(xué)方法評(píng)估個(gè)體CPM功能.然后,從人口統(tǒng)計(jì)學(xué)、生理學(xué)和心理學(xué)幾個(gè)方面詳細(xì)探討了影響個(gè)體CPM功能的復(fù)雜因素,從而提示大家應(yīng)綜合考慮影響個(gè)體CPM效率的因素.最后,本文總結(jié)了CPM相關(guān)的臨床應(yīng)用,包括慢性疼痛預(yù)測(cè)與評(píng)估、鎮(zhèn)痛藥物劑量預(yù)測(cè)以及個(gè)體健康質(zhì)量評(píng)估等.本文既能加深對(duì)人類(lèi)疼痛調(diào)節(jié)功能潛在機(jī)制的理解,又能為臨床上慢性疼痛疾病的預(yù)測(cè)和評(píng)估提供參考依據(jù).
[Abstract]:Conditioned pain regulation (CPM) is an endogenous pain regulation, which indicates that persistent pain in one part of the body can inhibit pain perception caused by nociceptive stimuli applied to another part of the body. In this paper, the neurophysiological and biochemical mechanisms related to CPM are summarized, and the traditional psychophysical methods for measuring the efficiency of individual CPM are introduced, and the neurophysiological indexes for evaluating the efficiency of CPM based on EEG and functional magnetic resonance imaging techniques are summarized. It is suggested that the individual CPM function should be evaluated by the methods of psychophysics and neurophysiology. Then, from the aspects of demography, physiology and psychology, this paper discusses in detail the complex factors that affect the function of individual CPM, which suggests that we should consider the factors that affect the efficiency of individual CPM. Finally, the clinical application of CPM was summarized, including the prediction and evaluation of chronic pain, the dose prediction of analgesic drugs and the evaluation of individual health quality. This article can not only deepen the understanding of the potential mechanism of human pain regulation function, but also provide a reference for clinical prediction and evaluation of chronic pain diseases.
【作者單位】： 西南大學(xué)心理學(xué)部認(rèn)知與人格教育部重點(diǎn)實(shí)驗(yàn)室;遵義師范學(xué)院教育科學(xué)學(xué)院;
【基金】：國(guó)家自然科學(xué)基金(31200856,31471082,31500921)資助
【分類(lèi)號(hào)】：R402
，
本文編號(hào)：2190965
[Abstract]:Conditioned pain regulation (CPM) is an endogenous pain regulation, which indicates that persistent pain in one part of the body can inhibit pain perception caused by nociceptive stimuli applied to another part of the body. In this paper, the neurophysiological and biochemical mechanisms related to CPM are summarized, and the traditional psychophysical methods for measuring the efficiency of individual CPM are introduced, and the neurophysiological indexes for evaluating the efficiency of CPM based on EEG and functional magnetic resonance imaging techniques are summarized. It is suggested that the individual CPM function should be evaluated by the methods of psychophysics and neurophysiology. Then, from the aspects of demography, physiology and psychology, this paper discusses in detail the complex factors that affect the function of individual CPM, which suggests that we should consider the factors that affect the efficiency of individual CPM. Finally, the clinical application of CPM was summarized, including the prediction and evaluation of chronic pain, the dose prediction of analgesic drugs and the evaluation of individual health quality. This article can not only deepen the understanding of the potential mechanism of human pain regulation function, but also provide a reference for clinical prediction and evaluation of chronic pain diseases.
【作者單位】： 西南大學(xué)心理學(xué)部認(rèn)知與人格教育部重點(diǎn)實(shí)驗(yàn)室;遵義師范學(xué)院教育科學(xué)學(xué)院;
【基金】：國(guó)家自然科學(xué)基金(31200856,31471082,31500921)資助
【分類(lèi)號(hào)】：R402
，
本文編號(hào)：2190965
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