【摘要】：目的:探討靜脈注射釓對比劑的全身性不良反應發(fā)生情況。方法:利用對比劑安全信息系統(tǒng)的數(shù)據(jù),搜集行MR增強檢查的18540例連續(xù)患者的病例資料,對注射釓對比劑后的全身性反應進行統(tǒng)計,分析不良事件出現(xiàn)時間及其與對比劑的相關性,分為急性不良反應(1h)、遲發(fā)性不良反應(1h~1w)和晚遲發(fā)不良反應(1w)三類,進一步將不良反應分為輕、中、重度三類,分別進行統(tǒng)計分析。結果:18540例共發(fā)生全身性不良反應24例,總發(fā)生率為0.13%。急性不良反應16例(0.09%),其中輕度9例、中度4例、重度3例。遲發(fā)性不良反應8例(0.04%),其中輕度6例、中度2例。無晚遲發(fā)不良反應。結論:MR增強檢查注射釓對比劑發(fā)生全身性不良反應的概率很低,但有發(fā)生急性重度不良反應的可能,應予以關注。
[Abstract]:Objective: to investigate the occurrence of systemic adverse reactions of intravenous gadolinium contrast agent. Methods: using the data of contrast agent safety information system, the data of 18540 consecutive patients with Mr enhancement were collected, and the systemic response after gadolinium contrast injection was statistically analyzed. The occurrence time of adverse events and their correlation with contrast agents were analyzed and divided into three categories: acute adverse reactions (1h), delayed adverse reactions (1h~1w) and late delayed adverse reactions (1w). The adverse reactions were further divided into three categories: mild, moderate and severe. Statistical analysis was carried out respectively. Results there were 24 cases of systemic adverse reactions in 18540 cases, the total incidence was 0.13%. There were 16 cases (0.09%) of acute adverse reactions, including mild 9 cases, moderate 4 cases, severe 3 cases. Delayed adverse reactions were found in 8 cases (0.04%), including mild 6 cases and moderate 2 cases. There were no late adverse reactions. Conclusion the probability of systemic adverse reactions in contrast-gadolinium injection is very low, but the possibility of acute and severe adverse reactions should be paid attention to.
【作者單位】： 北京大學第一醫(yī)院醫(yī)學影像科;
【分類號】：R445.2

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