本文選題：社區(qū)獲得性肺炎 + 凝血��； 參考：《中華醫(yī)院感染學(xué)雜志》2016年19期

【摘要】：目的探討不同嚴(yán)重程度社區(qū)獲得性肺炎患者凝血與纖溶指標(biāo)變化,為該病的臨床診斷與治療提供參考依據(jù)。方法選取2013年6月-2016年1月醫(yī)院收治的社區(qū)獲得性肺炎患者160例為肺炎組,另選取同期健康者160名為對(duì)照組,并根據(jù)肺炎嚴(yán)重程度指數(shù)(PSI)將肺炎組患者分為高危、中危、低危,比較肺炎組患者與對(duì)照組的凝血、纖溶指標(biāo)。結(jié)果肺炎組患者抗凝血酶Ⅲ(AT-Ⅲ)、血小板計(jì)數(shù)(PLT)、凝血酶時(shí)間(TT)均明顯低于對(duì)照組,纖維蛋白原(FIB)、活化部分凝血活酶時(shí)間(APTT)、凝血酶原時(shí)間(PT)高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);肺炎組患者D-二聚體(D-D)、纖維蛋白(原)降解產(chǎn)物(FDPs)、組織纖溶酶原激活物(t-PA)、纖溶酶原激活物抑制物1(PAI-1)、中性粒細(xì)胞彈性蛋白酶(NE)等纖溶指標(biāo)均明顯高于對(duì)照組(P0.05);高危、中危、低�；颊逜T-Ⅲ、PLT、TT依次升高,APTT逐漸降低,組間差異有統(tǒng)計(jì)學(xué)意義(P0.05),不同PSI指數(shù)患者FIB及PT差異無(wú)統(tǒng)計(jì)學(xué)意義,高危、中危、低�；颊逥-D、FDPs、t-PA、PAI-1、NE等纖溶指標(biāo)均依次降低,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論社區(qū)獲得性肺炎患者FIB、APTT、D-D、FDPs等凝血、纖溶指標(biāo)均高于正常水平,且病情越嚴(yán)重,凝血、纖溶指標(biāo)異常程度越高。
[Abstract]:Objective to investigate the changes of coagulation and fibrinolysis in patients with community acquired pneumonia of different severity, and to provide reference for clinical diagnosis and treatment of the disease. Methods from June 2013 to January 2016, 160 patients with community-acquired pneumonia were selected as pneumonia group and 160 healthy persons as control group. According to the PSI, the patients in pneumonia group were divided into high risk group, middle risk group and low risk group. The coagulation and fibrinolysis indexes were compared between the pneumonia group and the control group. Results Antithrombin 鈪，

本文編號(hào)：2068179