本文選題：右丙亞胺 + 心理干預(yù)��； 參考：《中華腫瘤防治雜志》2016年S1期

【摘要】：目的探討右丙亞胺聯(lián)合心理干預(yù)對(duì)行含蒽環(huán)類(lèi)藥物化療的對(duì)乳腺癌患者心臟毒性的防護(hù)作用。方法篩選2014-06-2015-06于河北省唐山市開(kāi)灤總醫(yī)院行化療的乳腺癌患者76例,作為研究對(duì)象。所有患者均接受常規(guī)多西他賽聯(lián)合表阿霉素的TE方案化療,采用隨機(jī)數(shù)表法將所有患者分為觀察組與對(duì)照組,其中對(duì)照組患者在TE化療方案基礎(chǔ)上加用右丙亞胺治療,觀察組患者則在對(duì)照組基礎(chǔ)上施行心理干預(yù),比較兩組患者心臟毒性改善情況。結(jié)果兩組患者化療后左室射血分?jǐn)?shù)(LVEF)、心肌鈣蛋白T(cTnt)、肌酸激酶同工酶(CK-MB)水平均較治療前發(fā)生明顯改變,但觀察組患者改變幅度更小,與對(duì)照組化療后比較存在顯著差異,P0.05;觀察組患者化療不良反應(yīng)檢出陽(yáng)性率明顯低于對(duì)照組,P0.05,差異有統(tǒng)計(jì)學(xué)意義。結(jié)論乳腺癌患者在常規(guī)化療方案基礎(chǔ)上加用右丙亞胺可有效降低化療藥物的心臟毒性,而聯(lián)合心理干預(yù)則可進(jìn)一步降低心臟功能損傷,對(duì)預(yù)防化療不良反應(yīng)具有重要作用。
[Abstract]:Objective to investigate the protective effect of dextroimide combined with psychological intervention on cardiac toxicity of breast cancer patients treated with anthracycline chemotherapy. Methods 76 breast cancer patients who received chemotherapy in Kailuan General Hospital, Tangshan City, Hebei Province were selected from 2014-06 to 2015-06. All patients were treated with conventional docetaxel combined with epirubicin te regimen. All patients were divided into observation group and control group by random number table method. The patients in control group were treated with dextromine on the basis of te regimen. The patients in the observation group were treated with psychological intervention on the basis of the control group to compare the improvement of cardiac toxicity between the two groups. Results the levels of left ventricular ejection fraction (LVEF), cardiac troponin T (cTnt) and creatine kinase isoenzyme (CK-MB) were significantly changed in both groups after chemotherapy. Compared with the control group, there was a significant difference (P 0.05), and the positive rate of adverse reactions in the observation group was significantly lower than that in the control group (P 0.05), and the difference was statistically significant. Conclusion the addition of dextromine on the basis of conventional chemotherapy regimen in breast cancer patients can effectively reduce the cardiac toxicity of chemotherapeutic drugs, and the combination of psychological intervention can further reduce cardiac function injury and play an important role in the prevention of adverse reactions to chemotherapy.
【作者單位】： 唐山市開(kāi)灤總醫(yī)院;
【分類(lèi)號(hào)】：R473.73

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 曾令源;李曉昕;張宜山;付彬玉;;注射用右丙亞胺對(duì)阿霉素引起的心臟毒性的保護(hù)作用[J];藥學(xué)與臨床研究;2008年06期

2 趙曉紅;王智;周仲昊;宣e，

本文編號(hào)：2066663