5937例結(jié)核病患者非結(jié)核分枝桿菌感染及其對(duì)抗結(jié)核藥物耐藥情況分析
本文選題:非結(jié)核分枝桿菌 + 結(jié)核病; 參考:《山東醫(yī)藥》2016年12期
【摘要】:目的分析結(jié)核病患者非結(jié)核分枝桿菌(NTM)感染及其對(duì)抗結(jié)核藥物耐藥情況。方法研究對(duì)象為2008~2014年青島市胸科醫(yī)院收治的5 937例結(jié)核病患者,從其痰液、支氣管灌洗液、胸腔積液、腹腔積液、胸壁組織、膿液、分泌物、腦脊液、尿液、糞便等標(biāo)本分離培養(yǎng)出分枝桿菌5 937株;采用生化反應(yīng)法進(jìn)行NTM菌種鑒定;采用羅氏培養(yǎng)基為基礎(chǔ)的絕對(duì)濃度法進(jìn)行NTM對(duì)異煙肼(INH)、鏈霉素(SM)、利福平(RFP)、乙胺丁醇(EMB)、對(duì)氨基水楊酸(PAS)、阿米卡星(AMK)、丙硫異煙胺(TH)、左氧氟沙星(LOFL)、力克肺疾(PNA)9種抗結(jié)核藥物的藥敏試驗(yàn)。結(jié)果 2008~2014年NTM總檢出率為2.86%(170/5 937),2012年檢出率最低為1.80%(15/831),2010年檢出率最高為3.62%(27/746)。NTM對(duì)INH的耐藥率為92.35%、PAS為91.76%、PNA為78.82%、TH為73.52%、EMB為67.05%、LOFL為63.52%、SM為50.58%、RFP為45.88%、AMK為31.76%。結(jié)論結(jié)核病患者中NTM檢出率較高(2.86%),對(duì)常用抗結(jié)核藥物耐藥率亦較高。
[Abstract]:Objective to analyze the non-tuberculosis mycobacterium (NTM) infection and its anti-tuberculosis drug resistance in patients with tuberculosis. Methods from 2008 to 2014, 5,937 patients with tuberculosis were treated in Qingdao chest Hospital. Sputum, bronchial lavage fluid, pleural effusion, celiac effusion, chest wall tissue, pus, secretion, cerebrospinal fluid and urine were studied. 5937 strains of Mycobacterium were isolated from feces and other specimens, and the strains of NTM were identified by biochemical reaction. Nine antituberculous effects of NTM on isoniazid (INH), streptomycin (SM), rifampicin (RFP), ethambutanol (EMB), p-aminosalicylic acid (pas), amikacin (AMK), propyleneisoniamin (th), levofloxacin (LOFL), rifampicin (RFP), aminosalicylic acid (pas), amicacin (AMK), propylenionomine (th), levofloxacin (LOFL), and lung disease (PNA) were studied using the absolute concentration method based on Roche medium. Drug sensitivity test. Results the total detection rate of NTM in 2008 ~ 2014 was 2.86% (170 / 5,937), the lowest was 1.80% (15 / 831) in 2012, and the highest detection rate was 3.62% (27 / 746) in 2010. The resistance rate of NTM to INH was 92.35% (27 / 746). Conclusion the positive rate of NTM in tuberculosis patients is high (2.86%), and the rate of resistance to common anti-tuberculosis drugs is also high.
【作者單位】: 青島市胸科醫(yī)院;青島大學(xué)醫(yī)學(xué)院第二附屬醫(yī)院;山東大學(xué)齊魯醫(yī)院;
【分類號(hào)】:R446.5;R52
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