發(fā)布時(shí)間：2018-06-10 11:40

  本文選題：靜電紡絲 + 傷口敷料　； 參考：《青島大學(xué)》2016年碩士論文

【摘要】：靜電紡絲制備微納米纖維因具有獨(dú)特的性能優(yōu)勢在傷口敷料等醫(yī)學(xué)領(lǐng)域存在著巨大的應(yīng)用前景。為加快電紡技術(shù)在醫(yī)用敷料領(lǐng)域的應(yīng)用轉(zhuǎn)化進(jìn)程,本文以便攜電紡裝置作為移動(dòng)護(hù)理醫(yī)療設(shè)備,實(shí)現(xiàn)創(chuàng)面原位電紡敷料,簡化電紡敷料使用過程為出發(fā)點(diǎn)設(shè)計(jì)了電池驅(qū)動(dòng)、氣流輔助、小型熔體等多款便攜電紡裝置,并對其制備體內(nèi)外敷料的應(yīng)用可能性做了初步探究。首先,設(shè)計(jì)了一款小型化電池驅(qū)動(dòng)便攜手持靜電紡絲裝置并對其工作性能、紡絲材料和效果進(jìn)行了實(shí)驗(yàn)驗(yàn)證。該裝置以自身配制的鋰離子電池為工作電源,經(jīng)外殼封裝后只有成年人手掌大小,可以將高分子材料直接原位電紡在患者創(chuàng)面實(shí)現(xiàn)“定制紡絲”,及時(shí)有效保護(hù)傷口,簡化了電紡敷料使用過程。因不使用外部電源供電,攜帶方便,本裝置可作為家庭護(hù)理、現(xiàn)場急救、野外救助等醫(yī)療器材,很大程度上加快了電紡敷料從理論研究到生產(chǎn)實(shí)用的轉(zhuǎn)化進(jìn)程。其次,驗(yàn)證了氣流輔助靜電紡絲裝置用于制備氰基丙烯酸酯醫(yī)用膠體內(nèi)止血敷料的生物安全性。外加氣流可精確控制膠體纖維的沉積范圍,有效避免組織粘連,提高操作安全性。相較于傳統(tǒng)止血材料使用方式,該裝置在大鼠肝切除創(chuàng)面直接原位電紡膠體止血敷料,可明顯降低膠體使用量,加快傷口愈合速度,證明了新型靜電紡絲技術(shù)用于制備體內(nèi)敷料的可行性、實(shí)用性及優(yōu)勢,為電紡技術(shù)的生物醫(yī)學(xué)應(yīng)用提供了一個(gè)重要方向。最后,以Wimshurst感應(yīng)起電機(jī)為工作電源,設(shè)計(jì)了一種熔體原位靜電紡絲裝置并對其工作原理和操作過程做了詳細(xì)介紹。使用該電紡裝置成功制備了聚乳酸、聚己內(nèi)酯生物微納米纖維,電紡纖維接觸生物組織時(shí)的溫度及其與生物組織的粘合力測試證明該熔體電紡裝置制備纖維在傷口敷料應(yīng)用上的可行性,有效避免了溶液電紡敷料中存在的殘余溶劑毒性問題,推進(jìn)了熔體電紡技術(shù)在傷口敷料應(yīng)用上的發(fā)展速度。
[Abstract]:Microfibers prepared by electrostatic spinning have great application prospects in wound dressing and other medical fields because of their unique performance advantages. In order to speed up the process of application and transformation of electrospinning technology in the field of medical dressing, this paper designed the battery drive with portable electrospinning device as the mobile nursing medical equipment, realizing the wound in situ electrospinning dressing and simplifying the process of electrospinning dressing. A number of portable electrospinning devices, such as airflow assisted and small melt, were studied. The possibility of their application in preparation of in vivo and in vitro dressings was also discussed. Firstly, a portable electrostatic spinning device driven by miniaturized battery is designed and its performance, spinning material and effect are verified experimentally. The device uses the self-made lithium ion battery as the working power source and has only the size of the adult palm after the shell package. It can directly and in-situ electrospun the polymer material to realize "custom spinning" in the wound of the patient, so as to protect the wound in time and effectively. The application process of electrospun dressing is simplified. This device can be used as medical equipment such as home nursing, field first aid, field rescue and so on because it does not use external power supply and is convenient to carry. It speeds up the transformation process of electrospun dressing from theoretical research to practical production to a great extent. Secondly, the biological safety of the air-assisted electrostatic spinning device for the preparation of cyanoacrylate medical adhesive in vivo hemostatic dressing was verified. The applied airflow can accurately control the deposition range of colloidal fibers, effectively avoid tissue adhesion and improve the safety of operation. Compared with the traditional way of using hemostatic material, the device can directly spin the colloidal hemostatic dressing directly in situ on the rat hepatectomy wound, which can obviously reduce the amount of colloid used and accelerate the wound healing speed. It is proved that the new electrospinning technology is feasible, practical and advantageous for the preparation of in vivo dressing, which provides an important direction for the biomedical application of electrospinning technology. Finally, a melt in situ electrostatic spinning device is designed with Wimshurst induction motor as the working power source. The working principle and operation process of the device are introduced in detail. Poly (lactic acid) and poly (caprolactone) biological nanofibers were successfully prepared by using the electrospinning apparatus. The temperature of electrospun fiber in contact with biological tissue and its adhesive force with biological tissue proved the feasibility of preparing fiber in wound dressing by this melt electrospinning device, and the residual solvent toxicity problem in solution electrospun dressing was effectively avoided. The development speed of melt electrospinning technology in wound dressing application was promoted.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R47

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本文編號(hào)：2003091