本文選題：顱內(nèi)感染 + 病原菌分布��； 參考：《中華醫(yī)院感染學(xué)雜志》2016年20期

【摘要】：目的對神經(jīng)介入治療患者顱內(nèi)感染病原菌的分布及藥敏性進行分析,為臨床治療提供參考依據(jù)。方法選取醫(yī)院2010年8月-2015年10月行神經(jīng)介入治療患者845例,脊髓穿刺法獲取腦脊液標本,采用法國生物梅里埃公司VITEK-2Compact儀器進行菌種鑒定,并進行耐藥性分析。結(jié)果 845例患者中分離出病原菌276株,其中革蘭陰性菌138株占50.00%,革蘭陽性菌86株占31.16%,真菌52株占18.84%;鮑氏不動桿菌、銅綠假單胞菌及肺炎克雷伯菌對氨芐西林、青霉素耐藥率100.00%,肺炎克雷伯菌對亞胺培南、美羅培南的耐藥率為10.71%、7.14%;金黃色葡萄球菌及表皮葡萄球菌對青霉素、頭孢西丁的耐藥率為100.00%;新型隱球菌對伏立康唑、氟康唑、兩性霉素B敏感。結(jié)論神經(jīng)內(nèi)科介入治療患者顱內(nèi)感染以革蘭陰性菌為主要病原菌,對多種抗感染類藥物耐藥性較高。
[Abstract]:Objective to analyze the distribution and drug sensitivity of pathogenic bacteria in patients with intracranial infection after nerve interventional therapy, and to provide reference for clinical treatment. Methods from August 2010 to October 2015, 845 patients were treated with interventional nerve therapy. Cerebrospinal fluid (CSF) samples were obtained by spinal cord puncture. The bacteria were identified by VITEK-2Compact instrument of French Bio-Meridier Company, and drug resistance was analyzed. Results 276 strains of pathogenic bacteria were isolated from 845 patients, of which 138 were Gram-negative bacteria, 86 Gram-positive bacteria accounted for 31.16 and 52 fungi accounted for 18.840.Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae were used to treat ampicillin. The resistance rate of Klebsiella pneumoniae to imipenem and meropenem was 10.71and 7.14; the resistance rate of Staphylococcus aureus and Staphylococcus epidermidis to penicillin and cefoxitin was 100.000.The resistance rate of Cryptococcus neoformans to Volconazole and fluconazole was 100.00.The resistance rate of Klebsiella pneumoniae to imipenem and meropenem was 10.71and 7.14. Amphotericin B is sensitive. Conclusion Gram-negative bacteria are the main pathogens in patients with intracranial infection after interventional therapy in neurology department.
【作者單位】： 青島市第三人民醫(yī)院神經(jīng)內(nèi)科;上海華山醫(yī)院放射科;
【基金】：山東省醫(yī)藥衛(wèi)生科技基金項目(2010K1304)
【分類號】：R446.5;R197.3
，

本文編號：1980084