本文選題：骨化三醇 + 西那卡塞��； 參考：《海南醫(yī)學院學報》2016年24期

【摘要】：目的:探討骨化三醇、西那卡塞聯(lián)合護理干預對維持性血液透析(MHD)患者繼發(fā)性甲狀旁腺功能亢進(SHPT)血清成纖維細胞生長因子23(FGF23)的影響。方法:選取我院收治的SHPT患者90例為研究對象,隨機分為觀察組和對照組。兩組均給予護理干預,于進食時吞服鹽酸西那卡塞,開始劑量為25mg/d,每2~4周根據(jù)全段甲狀旁腺激素(iPTH)、鈣(Ca)、磷(P)水平調整劑量,最大劑量不超過75mg/d,觀察組在上述治療基礎上口服骨化三醇膠丸0.25μg/d,3次/周,兩組均治療3個月后進行效果評價。兩組治療前后采集清晨空腹外周靜脈血,采用比色法測定Ca、P,ELISA法測定iPTH及血清FGF23、骨特異性堿性磷酸酶(BSAP),全自動生化檢測儀測定血肌酐(Scr)、尿毒氮(BUN),單室尿素動力學模型進行量化分析檢測尿素清除指數(shù)(KT/V)。結果:觀察組治療后Ca升高程度,P、iPTH降低程度大于對照組(P0.05),兩組治療后BUN、Scr、KT/V無明顯變化(P0.05),觀察組治療后FGF23、BSAP水平降低程度大于對照組(P0.05)。結論:骨化三醇、西那卡塞聯(lián)合護理干預治療MHD患者SHPT,可有效降低PTH、FGF23、BSAP水平,改善臨床癥狀。
[Abstract]:Objective: to investigate the effect of ossifying triol and combined nursing intervention with Sinakaser on serum fibroblast growth factor 23 FGF23 in secondary hyperparathyroidism parathyroid hyperparathyroidism (SHPTT) patients with maintenance hemodialysis (HD). Methods: 90 patients with SHPT were randomly divided into observation group and control group. The two groups were given nursing intervention. The initial dose was 25mg / d. The dose was adjusted every 2 weeks according to the levels of the whole level of parathyroid hormone iPTHG, calcium, phosphoric acid. The maximum dose was not more than 75 mg / d. The observation group took 0.25 渭 g / d of oscitic triol colloidal pill three times a week on the basis of the above treatment. The effect was evaluated after 3 months of treatment in both groups. Fasting peripheral venous blood was collected before and after treatment in both groups. IPTH and serum FGF23 were determined by colorimetric method, bone specific alkaline phosphatase (BSAP), serum creatinine (creatinine), urinary nitrogen bun, urea clearance index (KT / V) were determined by single chamber urea kinetic model. Results: the degree of Ca increase in the observation group was higher than that in the control group (P 0.05), but there was no significant change in KT / V between the two groups after treatment. The decrease of the level of FGF23 / BSAP in the observation group was higher than that in the control group (P 0.05). Conclusion: combined nursing intervention of ossifying triol and Sinakaser can effectively reduce the level of FGF23 BSAP and improve clinical symptoms in patients with MHD.
【作者單位】： 河北北方學院附屬第二醫(yī)院五官科病房;河北北方學院附屬第二醫(yī)院腎內科;
【基金】：張家口市科學技術和地震局計劃項目(1521095D)~~
【分類號】：R473.5

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相關期刊論文 前10條

1 繆立英;金麗娜;沈建琴;朱濱;;西那卡塞對維持性血液透析繼發(fā)甲狀旁腺功能亢進患者血清FGF-23的影響[J];江蘇醫(yī)藥;2016年13期

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本文編號：1933106