本文選題：膿毒癥 + 心肌損傷��； 參考：《實用醫(yī)學雜志》2016年23期

【摘要】：目的:觀察心型脂肪酸結(jié)合蛋白(H-FABP)和可溶性CD14亞型(Presepsin)在丹參川芎嗪治療膿毒癥心肌損傷患者中的變化及意義。方法:114例膿毒癥心肌損傷患者隨機分成對照組和治療組,對照組給予常規(guī)治療,治療組在對照組基礎(chǔ)上加丹參川芎嗪�；颊咧委熐凹爸委�6 h、3 d,檢測H-FABP、Presepsin、肌鈣蛋白I(cTnI)及N-末端腦鈉肽前體(NT-proBNP)的變化,觀察治療前后LVEF、SOFA評分、主要心臟不良事件(MACE)發(fā)生率及28 d病死率。結(jié)果:治療6 h,治療組H-FABP、Presepsin、cTnI和NT-proBNP低于對照組(P0.05),兩組H-FABP、cTnI和NT-proBNP高于治療前,Presepsin低于治療前(P0.05)。治療3 d,兩組cTnI和NT-proBNP較治療6 h升高,Presepsin較治療6 h降低(P0.05),對照組Presepsin、cTnI和NT-proBNP高于治療組(P0.05)。治療組治療后SOFA評分、LVEF、累計MACE發(fā)生率和28 d病死率低于對照組(P0.05)�；颊逪-FABP與SOFA評分呈正相關(guān)(P0.05)。結(jié)論:丹參川芎嗪能降低患者H-FABP、Presepsin、cTnI和NT-proBNP,改善LVEF,降低28 d病死率,減少MACE發(fā)生,為指導臨床治療提供依據(jù)。
[Abstract]:Aim: to observe the changes and significance of cardiac fatty acid binding protein (H-FABP) and soluble CD14 subtype presepsin in the treatment of septic myocardial injury with Salvia miltiorrhiza Ligustrazine. Methods 114 patients with septic myocardial injury were randomly divided into control group and treatment group. The control group was treated with routine therapy, and the treatment group was treated with salvia miltiorrhiza ligustrazine on the basis of control group. The changes of H-FABPP-Presepsin, cardiac troponin I cTnI and NT-proBNPs were detected before and after treatment. The LVEFSFA scores, the incidence of major adverse cardiac events (MACEE) and the fatality rate of 28 days were observed before and after treatment. Results: at 6 h after treatment, the levels of H-FABPnI and NT-proBNP in the treatment group were lower than those in the control group (P 0.05), and the levels of H-FABPnI and NT-proBNP in the two groups were higher than those in the pre-treatment group (P 0.05). On the 3rd day of treatment, cTnI and NT-proBNP in both groups were significantly higher than those in the treatment group at 6 h. The levels of presepsin cTnI and NT-proBNP in the control group were significantly higher than those in the treatment group at 6 h after treatment, and the levels of P0.05G in the control group were higher than those in the control group. After treatment, the SOFA score, cumulative MACE incidence and fatality rate in the treatment group were lower than those in the control group (P 0.05). There was a positive correlation between H-FABP and SOFA score (P 0.05). Conclusion: Salvia miltiorrhiza tetramethylpyrazine can reduce the H-FABPP-presepsinsinsinsinsintosine cTnI and NT-proBNPs, improve LVEF, reduce the fatality rate of 28 days, reduce the incidence of MACE, and provide the basis for guiding clinical treatment.
【作者單位】： 河北醫(yī)科大學附屬哈勵遜國際和平醫(yī)院急救醫(yī)學部;河北醫(yī)科大學附屬哈勵遜國際和平醫(yī)院重癥醫(yī)學科;
【基金】：衡水市科學技術(shù)研究與發(fā)展計劃項目(編號:15019)
【分類號】：R459.7;R542.2

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