本文選題：全氟辛烷磺酸 + 全氟辛酸��； 參考：《生態(tài)毒理學(xué)報(bào)》2016年01期

【摘要】：目的:全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)是廣泛應(yīng)用于工業(yè)和生活領(lǐng)域的全氟化合物,在人體及環(huán)境介質(zhì)中均可檢出。近幾年的流行病學(xué)研究表明兒童PFOS和PFOA的暴露水平與血脂水平具有相關(guān)性。本研究擬進(jìn)一步研究血清全氟化合物水平與兒童血脂間關(guān)聯(lián)的性別差異。方法:以臺(tái)灣兒童為研究對象,分析血清中總膽固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、甘油三脂(TG)等生化指標(biāo)與PFOS和PFOA血清水平的相關(guān)性。結(jié)果:線性回歸模型分析表明男生血清PFOS、PFOA水平與血脂水平具有顯著相關(guān)性。當(dāng)男生血清中l(wèi)n-PFOS和ln-PFOA水平每增加1 ng·m L~(-1)時(shí),TC含量分別增高0.51 mg·d L~(-1)(95%CI:0.30~0.72)和6.53 mg·d L~(-1)(95%CI:1.96~11.11),但在女生中則沒有觀察到血清PFOS和PFOA水平與TC的相關(guān)性。趨勢分析結(jié)果顯示,隨著兒童血清中PFOS和PFOA水平的增加,男生和女生血脂的TC、LDL和TG含量呈增高趨勢。結(jié)論:臺(tái)灣兒童血清PFOS和PFOA水平與血脂水平存在正相關(guān),且在男生中觀察到的效應(yīng)強(qiáng)于女生。
[Abstract]:Objective: perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOAA) are widely used in industrial and living fields and can be detected in human and environmental media. Epidemiological studies in recent years have shown that exposure levels of PFOS and PFOA are correlated with serum lipids in children. The aim of this study was to study the gender difference between serum perfluorides and serum lipids in children. Methods: the correlation between serum total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG) and serum levels of PFOS and PFOA were analyzed in children in Taiwan. Results: the linear regression analysis showed that there was a significant correlation between serum PFOS- PFOA level and blood lipid level in male students. When the serum levels of ln-PFOS and ln-PFOA in male students increased by 1 ng mL / L), the levels of TC were increased by 0.51 mg / d / L ~ (95) CI: 0.30 ~ 0.72) and 6.53 mg / d / L ~ (95) CI: 1.96 / 11.11%, respectively. However, there was no correlation between serum PFOS and PFOA levels and TC in female students. The results of trend analysis showed that with the increase of serum levels of PFOS and PFOA in children, the levels of TCL-LDL and TG in serum of boys and girls showed an increasing trend. Conclusion: there is a positive correlation between serum PFOS and PFOA levels and blood lipid levels in Taiwanese children, and the effect is stronger in boys than in girls.
【作者單位】： 中山大學(xué)公共衛(wèi)生學(xué)院預(yù)防醫(yī)學(xué)系;中山大學(xué)中山醫(yī)學(xué)院;廣州市環(huán)境污染與健康風(fēng)險(xiǎn)評(píng)價(jià)重點(diǎn)實(shí)驗(yàn)室;國立臺(tái)灣大學(xué)公共衛(wèi)生學(xué)院預(yù)防醫(yī)學(xué)研究所;
【基金】：國家自然科學(xué)基金項(xiàng)目(81472936,81172630) 廣東省自然科學(xué)基金項(xiàng)目(2014A030313021)
【分類號(hào)】：R446.11
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本文編號(hào)：1880198