本文選題：直抗 + 直接抗球蛋白試驗(yàn)��； 參考：《中國(guó)輸血雜志》2016年11期

【摘要】：目的通過研究直抗陽(yáng)性血樣的血清學(xué)特點(diǎn),探討不同的簡(jiǎn)化配血方案的安全性。(常見的簡(jiǎn)化方法包括盲配后挑選反應(yīng)較弱血液的供血;主側(cè)配血與自身對(duì)照比較后的供血;ABO、Rh同型供血等)。方法回顧性分析本中心2013年11月-2015年6月直抗陽(yáng)性患者101名和歷年輸血不良反應(yīng)患者17例,其血清或放散液均經(jīng)過同種或類同種抗體鑒定。通過分析其自身對(duì)照,抗體篩選,鑒定試驗(yàn),配血試驗(yàn)的反應(yīng)結(jié)果,判斷不同簡(jiǎn)化的配血方法可能存在的風(fēng)險(xiǎn)。結(jié)果統(tǒng)計(jì)未檢出特異性抗體占59.32%(70/118);檢出同種抗體及/或自身抗體占37.29%(44/118);檢出類同種特異性抗體占3.39%(4/118);其中確定為Rh抗體占89.58%(43/48)、確定為Rh以外的其它抗體占10.41%(5/48);118例DAT陽(yáng)性患者在聚凝胺及抗人球反應(yīng)介質(zhì)下配血時(shí),主側(cè)配血管反應(yīng)強(qiáng)度大于自身對(duì)照管占28.57%(28/98)、主側(cè)配血管小于自身對(duì)照管占71.43%(70/98)。結(jié)論對(duì)于DAT陽(yáng)性患者,各種簡(jiǎn)化配血方法中,ABO、Rh同型輸血風(fēng)險(xiǎn)較低,主側(cè)配血與自身對(duì)照比較后的供血方法以及盲配方法的風(fēng)險(xiǎn)較大。
[Abstract]:Objective to study the serological characteristics of direct anti-positive blood samples and to explore the safety of different simplified blood matching protocols. (the common simplified methods include the selection of blood supply of weaker blood after blind matching, and the homotypic blood supply of ABOOG Rh after main side matching and self control. Methods from November 2013 to June 2015, 101 patients with positive direct antibody and 17 patients with adverse reaction of transfusion in our center were retrospectively analyzed. Their serum or exuberant were identified by homologous or similar antibodies. By analyzing the results of autocontrol, antibody screening, identification test and blood matching test, the possible risks of different simplified blood matching methods were judged. Results No specific antibody was detected (59.32% / 118g); homoantibodies and / or autoantibodies were detected in 37.29% of 118g / 118s; and the same specific antibodies were detected in 3.39g / 4 / 118G; Rh antibodies were identified as Rh antibodies (89.58% / 48C), and other antibodies other than Rh antibodies accounted for 10.41r548t / 118 cases of DAT positive patients. In the medium of polyglutamide and antihuman sphere reaction, The reaction intensity of the main collateral vessels was more than that of the autocontrol vessels (28.57 / 98) and the main collateral vessels were less than that of the self-control vessels (71.43% / 98%). Conclusion for DAT positive patients, the risk of homotypic blood transfusion is lower in all kinds of simplified matching methods, and the risk of blood supply method and blind matching method after main side blood matching is higher than that of self-control.
【作者單位】： 上海市血液中心;
【基金】：上海市公共衛(wèi)生重點(diǎn)學(xué)科建設(shè)項(xiàng)目(15GWZK0501)
【分類號(hào)】：R457.11

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