本文選題：耐甲氧西林金黃色葡萄球菌 + 多位點(diǎn)序列分析�。� 參考：《中華醫(yī)院感染學(xué)雜志》2016年23期

【摘要】：目的對(duì)耐甲氧西林金黃色葡萄球菌(MRSA)進(jìn)行多位點(diǎn)序列分析(MLST),初步了解泉州地區(qū)MRSA的MLST分型、MRSA的耐藥性與ST及ST克隆系的相關(guān)性方法收集2013-2015年本地區(qū)分離47株MRSA,采用MLST對(duì)受試菌的7個(gè)等位基因進(jìn)行序列分析,同時(shí)進(jìn)行網(wǎng)上數(shù)據(jù)庫(kù)比對(duì),得到每個(gè)菌株相應(yīng)的等位基因號(hào)。結(jié)果 47株菌分為14個(gè)ST型,2個(gè)型別為新的型別(已提交未反饋)。每個(gè)型別包含1-17株菌。ST59是優(yōu)勢(shì)型別(36.2%),包含17株菌;其次為ST239(17.0%),包含8株菌;ST59分布于2013年、2014年、2015年,表示該型別菌株在本地區(qū)長(zhǎng)期存在;ST59分布于3所醫(yī)院,表示該型別菌株本地區(qū)廣泛分布。結(jié)論本地區(qū)MRSA分離株基因多態(tài)性大,ST59和ST239是本地區(qū)MRSA分離株的優(yōu)勢(shì)ST型。
[Abstract]:Objective to study the multilocus sequence analysis of methicillin-resistant staphylococcus aureus (MRSA), and to investigate the correlation between the drug resistance of MRSAs and St and St clones in Quanzhou area. Methods 47 strains of MRSAs were collected from our region from 2013 to 2015. Seven alleles of tested bacteria were sequenced by MLST. At the same time, the corresponding allele number of each strain was obtained by comparing the online database. Results 47 strains were divided into 14 St types and 2 new types. Each type contains 1 to 17 strains of bacteria. ST59 is the dominant type, including 17 strains, followed by ST239 / 17.0 and 8 strains of ST59 distributed in 2013, 2014 and 2015, indicating that the strain has long existed in three hospitals in the region, It indicates that this type of strain is widely distributed in this region. Conclusion ST59 and ST239 are the dominant St type of MRSA isolates in our region.
【作者單位】： 福建醫(yī)科大學(xué)附屬第二醫(yī)院檢驗(yàn)科;泉州市第一醫(yī)院;泉州醫(yī)學(xué)高等專科學(xué)校;
【分類號(hào)】：R446.5
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本文編號(hào)：1778553