本文選題：重癥監(jiān)護(hù)病房 + 金黃色葡萄球菌��； 參考：《中國(guó)感染控制雜志》2016年05期

【摘要】：目的了解某院重癥監(jiān)護(hù)病房(ICU)金黃色葡萄球菌的耐藥特點(diǎn)及分子流行病學(xué)特征。方法收集2014年1—12月該院ICU分離的金黃色葡萄球菌,進(jìn)行細(xì)菌鑒定及藥物敏感性試驗(yàn),采用金黃色葡萄球菌A蛋白(spa)分型及多位點(diǎn)序列分型(MLST)方法進(jìn)行分型。結(jié)果 160株金黃色葡萄球菌中耐甲氧西林金黃色葡萄球菌(MRSA)120株(占75.00%)。MRSA對(duì)紅霉素、克林霉素、左氧氟沙星的耐藥率均80%;MSSA對(duì)頭孢唑林敏感,對(duì)紅霉素、克林霉素、左氧氟沙星的耐藥率分別為62.50%、35.00%、10.00%。spa分型和MLST結(jié)果顯示,120株MRSA主要為ST239-t030、ST239-t037、ST5-t2460 3種型別,其中ST239-t030(105株,87.50%)為主要流行菌株,8個(gè)ICU均有檢出;MSSA存在較多型別,ST59-t437僅在神經(jīng)內(nèi)科(8株)和消化科(2株)檢出,ST6-t701、ST398-t3625、ST398-t1793和ST121-t2092分別僅在神經(jīng)內(nèi)科(7株)、麻醉科(5株)、神經(jīng)外科(4株)和心外科(4株)檢出。結(jié)論該院ICU MRSA分離率較高,以ST239-t030克隆株為主,存在醫(yī)院內(nèi)流行;不同型別MSSA在各科室內(nèi)存在流行趨勢(shì)。
[Abstract]:Objective to investigate the characteristics of drug resistance and molecular epidemiology of staphylococcus aureus in intensive care unit (ICU).Methods Staphylococcus aureus isolated from January to December 2014 in our hospital was collected for bacterial identification and drug sensitivity test. Staphylococcus aureus A protein spares typing and multiple locus sequence typing were used to type Staphylococcus aureus.Results among the 160 strains of Staphylococcus aureus, 120 strains of methicillin-resistant Staphylococcus aureus (75.00%).MRSA) were resistant to erythromycin, clindamycin, levofloxacin, and were sensitive to cefazolin, erythromycin and clindamycin.The drug resistance rates of levofloxacin were 62.50 and 35.00, respectively. The results of SPA typing and MLST analysis showed that there were three types of ST239-t037ST5-t2460 in MRSA, which were divided into two groups: ST239-t030, ST239-t037ST5-t2460, ST239-t037ST5-t2460, ST239-t037ST5-t2460.Among them, ST239-t030(105 strain (87.50) was the main prevalent strain. There were 8 strains of ST59-t437 in neurology and 2 strains in digestive department.) ST6-t701, ST398-t3625 ST398-t1793 and ST121-t2092 were detected only in 7 strains of neurology, 5 strains of anesthesiology and 4 strains of neurosurgery, respectively.Strain) and cardiac surgery (4 strains) were detected.Conclusion the isolation rate of ICU MRSA in our hospital is high, the clone of ST239-t030 is the main one, and the different types of MSSA are prevalent in different departments.
【作者單位】： 第四軍醫(yī)大學(xué)西京醫(yī)院全軍臨床檢驗(yàn)醫(yī)學(xué)研究所;
【基金】：陜西省自然科學(xué)基金資助項(xiàng)目(2014JM4188)
【分類號(hào)】：R446.5

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