本文選題：膿毒癥　切入點(diǎn)：降鈣素原　出處：《山東醫(yī)藥》2016年01期

【摘要】：目的探討指導(dǎo)ICU膿毒癥患者抗生素停用的血清降鈣素原(PCT)最佳水平范圍。方法收入ICU的158例膿毒癥患者,全部按照抗生素使用指南及臨床經(jīng)驗(yàn)進(jìn)行抗生素治療。檢測所有患者停用抗生素時(shí)血清PCT水平,按血清PCT水平分為A、B、C、D、E、F組,其PCT水平分別為0.1、0.1~0.25、0.25~0.5、0.5~2、2~10、≥10 ng/m L,比較各組入院28 d內(nèi)的病死率、抗生素使用時(shí)間及住院時(shí)間。結(jié)果 C、D、E、F組較A、B組病死率增加(P均0.05);C、D、E、F組中,除C組與F組以及D組與F組患者病死率比較差異有統(tǒng)計(jì)學(xué)意義(P均0.05),其余各組病死率比較差異無統(tǒng)計(jì)學(xué)意義(P均0.05);A、B組病死率比較差異無統(tǒng)計(jì)學(xué)意義(P0.05),但A組較B組抗生素使用時(shí)間與住院時(shí)間增加(P分別為0.023、0.021)。結(jié)論 ICU膿毒癥患者血清PCT水平在0.1~0.25 ng/m L時(shí)宜停用抗生素。
[Abstract]:Objective to explore the optimal range of serum procalcitonin (ICU) levels for patients with ICU sepsis to stop using antibiotics. Methods 158 patients with ICU were enrolled in the study. All patients were treated with antibiotics according to the guidelines of antibiotic use and clinical experience. The serum PCT level was measured when all patients stopped using antibiotics. The PCT levels of the two groups were 0. 1 / 0. 1 ~ 0. 25 ~ 0. 25 ~ 0. 5 ~ 0. 5 / 2 ~ (2 +), 鈮，

本文編號(hào)：1664078