本文選題：肝腫瘤　切入點：腫瘤　出處：《中國醫(yī)學(xué)影像學(xué)雜志》2016年11期 　論文類型：期刊論文

【摘要】：目的探討3D非剛性運動校正在肝腫瘤動態(tài)增強MRI(DCE-MRI)中的應(yīng)用價值。資料與方法回顧性分析2013年1月-2014年11月紹興市人民醫(yī)院經(jīng)病理證實為原發(fā)性肝細(xì)胞肝癌(HCC)及結(jié)直腸癌肝轉(zhuǎn)移的患者37例,分為原發(fā)性肝癌組(27例)與結(jié)直腸癌肝轉(zhuǎn)移組(10例)。分別對兩組患者數(shù)據(jù)行3D非剛性運動校正,并使用肝臟雙血供雙室血流動力學(xué)Extended Tofts模型計算各組容量轉(zhuǎn)移常數(shù)(K~(trans))、速率常數(shù)(K_(ep))、血管外細(xì)胞外容積分?jǐn)?shù)(V_e)、血漿容積分?jǐn)?shù)(V_p)、肝動脈供血比例(HPI)等定量參數(shù),同時測量病灶面積值,比較各組間運動校正前后腹主動脈和門靜脈時間-濃度曲線、病灶面積差異。運用ROC曲線比較各定量參數(shù)診斷效能。結(jié)果 3D非剛性運動校正后,門靜脈時間-濃度曲線具有更好的平滑性。運動校正前后原發(fā)性肝癌組K~(trans)值均大于結(jié)直腸癌肝轉(zhuǎn)移組,差異有統(tǒng)計學(xué)意義(P0.05);運動校正后原發(fā)性肝癌組V_p值大于結(jié)直腸癌肝轉(zhuǎn)移組,差異有統(tǒng)計學(xué)意義(P0.05)。運動校正前K~(trans)值的曲線下面積(AUC)為0.80,閾值為0.18/min,靈敏度為81%;運動校正后K~(trans)的AUC為0.85,閾值為0.20/min,靈敏度為87%。V_p的AUC為0.80,閾值為0.16/min,靈敏度為72%,特異度為89%。結(jié)論 3D非剛性運動校正在肝腫瘤DCE-MRI定量灌注中具有一定價值,可提高HCC與結(jié)直腸癌肝轉(zhuǎn)移的靈敏度。
[Abstract]:Objective to evaluate the value of 3D nonrigid motion correction in dynamic enhanced MRICE-MRI of liver neoplasms. Data and methods retrospective analysis of HCC and its nodule in Shaoxing people's Hospital from January 2013 to November 2014. 37 patients with liver metastases from rectal cancer, The patients were divided into primary liver cancer group (n = 27) and colorectal cancer liver metastasis group (n = 10). The volume transfer constant, rate constant, extracellular volume fraction (ECV), plasma volume fraction (VPP) and hepatic arterial blood supply ratio (HPI) were calculated by Extended Tofts model. The time-concentration curves of abdominal aorta and portal vein and the difference of focus area were compared between groups before and after motion correction. ROC curves were used to compare the diagnostic efficacy of quantitative parameters. The time-concentration curve of portal vein had better smoothness. Before and after exercise correction, the values of KT in HCC group were higher than those in colorectal cancer group. The difference was statistically significant (P 0.05), the VSP value of primary liver cancer group after exercise correction was higher than that of colorectal cancer liver metastasis group. The area under the curve is 0.80, the threshold is 0.18 / min, and the sensitivity is 81.The AUC of the Kni-Transfer after motion correction is 0.85, the threshold is 0.20 / min, the AUC of sensitivity is 0.80, the threshold is 0.16 / min, the sensitivity is 72 / min, the specificity is 0.20 / min, the sensitivity is 0.80, the threshold is 0.16 / min, the sensitivity is 72 / min, the threshold is 0.20 / min, the sensitivity is 0.20 / min, the sensitivity is 0.80 / min, the sensitivity is 0.16 / min, the sensitivity is 72 / min, and the sensitivity is 0.20 / min, respectively. Conclusion 3D nonrigid motion correction has certain value in DCE-MRI quantitative perfusion of liver tumors. It can improve the sensitivity of HCC and liver metastasis of colorectal cancer.
【作者單位】： 紹興市人民醫(yī)院(浙江大學(xué)紹興醫(yī)院)放射科;
【基金】：浙江省自然科學(xué)基金(LY16H180006) 浙江省公益性計劃(2014C33151) 浙江省醫(yī)藥衛(wèi)生一般研究計劃(2014KYA215);浙江省醫(yī)藥衛(wèi)生一般研究計劃(2016KYB306)
【分類號】：R735.7;R445.2

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本文編號：1614872