本文選題：病原菌　切入點：耐藥監(jiān)測　出處：《現(xiàn)代預(yù)防醫(yī)學(xué)》2016年18期 　論文類型：期刊論文

【摘要】：目的了解2013-2015年臨床細(xì)菌分布和耐藥性,為臨床合理使用抗菌藥物提供依據(jù)。方法對2013-2015年臨床病原菌分布及耐藥性進行回顧性研究。采用珠海迪爾醫(yī)學(xué)細(xì)菌測定系統(tǒng)對4 439株病原菌進行細(xì)菌鑒定和藥敏試驗。結(jié)果 2013-2015年臨床共分離4 439株病原菌,革蘭陰性菌占78.3%,革蘭陽性菌占17.6%,真菌占4.1%,其中革蘭陰性菌前4位依次為銅綠假單胞菌(22.2%)、肺炎克雷伯菌(16.5%)、大腸埃希菌(15.3%)和鮑曼不動桿菌(9.5%)。藥敏結(jié)果顯示,臨床常見病原菌對大部分抗菌藥物有不同程度耐藥且特點各不相同。3年中銅綠假單胞菌對頭孢哌酮/舒巴坦、哌拉西林/他唑巴坦、頭孢吡肟、阿米卡星、多黏菌素B和氨曲南的耐藥率始終低于30%,平均耐藥率分別為13.2%、17.5%、18.4%、9.5%、4.8%和8.1%。鮑曼不動桿菌對多黏菌素B耐藥率最低,為4.7%;耐藥率增幅最大的為阿米卡星,耐藥率由2013年的27.8%上升至2015年的75.0%。未發(fā)現(xiàn)對亞胺培南耐藥大腸埃希菌。肺炎克雷伯菌對美羅培南和亞胺培南的耐藥率分別為17.4%和16.6%。57.4%大腸埃希菌和18.8%肺炎克雷伯菌產(chǎn)超廣譜β-內(nèi)酰胺酶(ESBLs),泛耐藥鮑曼不動桿菌(PDR)檢出率為1.3%。未檢出對萬古霉素耐藥革蘭陽性球菌。耐甲氧西林金黃色葡萄球菌(MRSA)的檢出率為40.9%。結(jié)論醫(yī)院感染病原菌以革蘭陰性菌為主且耐藥率較高,需加強細(xì)菌耐藥性監(jiān)測,為合理用藥提供依據(jù)。
[Abstract]:Objective to investigate the distribution and drug resistance of clinical bacteria from 2013 to 2015, Methods the distribution and drug resistance of clinical pathogens from 2013 to 2015 were studied retrospectively. 4 439 strains of pathogenic bacteria were identified and drug sensitive by Zhuhai Deer Medical bacteria Test system. Results A total of 4,439 strains of pathogenic bacteria were isolated from the clinic between 2013 and 2015. Gram-negative bacteria accounted for 78.3%, Gram-positive bacteria 17.6% and fungi for 4.1%. Among them, the first four gram-negative bacteria were Pseudomonas aeruginosa 22.2um, Klebsiella pneumoniae 16.551.) and Acinetobacter baumannii 9.5. In 3 years, Pseudomonas aeruginosa had different resistance to cefoperazone / sulbactam, piperacillin / tazobactam, cefepime, amikacin, and so on. The drug resistance rates of polymyxin B and aztreonam were always lower than 30%, and the average drug resistance rates were 13. 2% and 17. 5% and 18. 4% and 8. 1%, respectively. Acinetobacter baumannii had the lowest resistance rate to polymyxin B, which was 4. 7%, and the highest rate of drug resistance was amikacin. The resistance rate of Klebsiella pneumoniae to meropenem and imipenem was 17.4% and 16.67.4% respectively. The detection rate of extended-spectrum 尾 -lactamase producing ESBLsN and pan-drug-resistant Acinetobacter baumannii was 1.3. The detection rate of vancomycin resistant Gram-positive cocci and methicillin-resistant Staphylococcus aureus MRSAs was 40.90.Conclusion Nosocomial infection is a pathogen of nosocomial infection. Gram-negative bacteria were the main bacteria and the drug resistance rate was higher. It is necessary to strengthen the monitoring of bacterial resistance and provide the basis for rational use of drugs.
【作者單位】： 鄭州鐵路職業(yè)技術(shù)學(xué)院醫(yī)學(xué)技術(shù)系;
【分類號】：R446.5

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 孔繁林,儲從家,管新龍,羅次節(jié);云南玉溪地區(qū)甲型副傷寒沙門菌的耐藥性變遷[J];中國臨床藥學(xué)雜志;2005年03期

2 戴學(xué)海;;老年患者銅綠假單胞菌感染及耐藥性變遷分析[J];浙江臨床醫(yī)學(xué);2008年03期

3 蔡篤運;施理;林鋒;賈杰;;類鼻疽伯克霍爾德菌耐藥性變遷臨床研究[J];現(xiàn)代預(yù)防醫(yī)學(xué);2010年06期

4 何敏;陳敏;易本馳;;加強重視動物源細(xì)菌的耐藥性監(jiān)測[J];中國動物保健;2011年04期

5 周淑群;韋柳華;周定球;;2008-2010年耐甲氧西林金黃色葡萄球菌的耐藥性變遷[J];中華醫(yī)院感染學(xué)雜志;2012年03期

6 宋建梅;耿蓉娜;張建芬;;多藥耐藥銅綠假單胞菌的分布特點及耐藥性變遷[J];河北醫(yī)藥;2013年19期

7 倪柏鋒;徐輝;顧小根;陳偉杰;趙靈燕;吳峗z，

本文編號：1597057