本文關(guān)鍵詞： 降鈣素原 發(fā)熱 熱程 嚴(yán)重細(xì)菌感染 系統(tǒng)評(píng)價(jià)　出處：《新疆醫(yī)科大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：探討降鈣素原(PCT)對(duì)不同熱程發(fā)熱兒童嚴(yán)重細(xì)菌感染(SBIs)的診斷價(jià)值。方法：計(jì)算機(jī)檢索獲得PCT對(duì)發(fā)熱兒童嚴(yán)重細(xì)菌感染診斷價(jià)值的文獻(xiàn),檢索時(shí)間為建庫至2014年7月,按照QUAD AS標(biāo)準(zhǔn)對(duì)納入文獻(xiàn)進(jìn)行質(zhì)量評(píng)估。使用MetaDisc1.4軟件進(jìn)行Meta分析,對(duì)不同平均熱程(24、～48和48h)PCT、WBC和中性粒細(xì)胞絕對(duì)計(jì)數(shù)(ANC)診斷SBIs的敏感度、特異度等指標(biāo)進(jìn)行匯總,并進(jìn)行異質(zhì)性檢驗(yàn),繪制綜合受試者工作特征曲線(SROC),計(jì)算曲線下面積(AUC)。使用Stata12.0軟件判斷發(fā)表偏倚并繪制漏斗圖。結(jié)果：初檢到442篇文獻(xiàn),11篇文獻(xiàn)符合納入標(biāo)準(zhǔn)進(jìn)入Meta分析(中文1篇,英文10篇)。①平均熱程24h對(duì)SBIs的診斷價(jià)值：PCT的匯總敏感度和特異度分別為0.75和0.80,SROC AUC為0.870；WBC的匯總敏感度和特異度分別為0.48和0.54,AUC為0.484;ANC的匯總敏感度和特異度分別為0.30和0.78。②平均熱程24～48h對(duì)SBIs的診斷價(jià)值：PCT的匯總敏感度和特異度分別為0.86和0.63,AUC為0.857；WBC的匯總敏感度和特異度分別為0.54和0.46,AUC為0.558；ANC的匯總敏感度和特異度分別為0.47和0.12。③平均熱程48h對(duì)SBIs的診斷價(jià)值：PCT的匯總敏感度和特異度分別為0.83和0.55,AUC為0.816；2篇WBC文獻(xiàn)的敏感度特分別為0.69和0.34,特異度分別為0.81和0.29；ANC的敏感度和特異度分別為0.87和0.40。結(jié)論：對(duì)發(fā)熱兒童診斷SBIs的價(jià)值,發(fā)熱24檢測(cè)PCT有較高的特異度；發(fā)熱24-48h檢測(cè)PCT有較高的敏感度。
[Abstract]:Objective: to investigate the diagnostic value of procalcitonin in the diagnosis of severe bacterial infection in children with fever of different fever course. Methods: the literature of PCT in the diagnosis of severe bacterial infection in febrile children was retrieved by computer, and the retrieval time was up to July 2014. The quality of the literature was evaluated according to the QUAD as standard. The sensitivity and specificity of different mean caloric cycles (24 ~ 48 and 48 h) and the absolute count of neutrophils (ANC) in the diagnosis of SBIs were summarized by Meta analysis with MetaDisc1.4 software. And test the heterogeneity, Using Stata12.0 software to judge publication bias and draw funnel diagram. Results: the first 442 articles and 11 articles met the inclusion criteria and entered the Meta analysis (1 in Chinese, 1 in Chinese), and 11 in accordance with the inclusion criteria (1 in Chinese, 1 in Chinese, 1 in Chinese) and 11 in accordance with the inclusion criteria (1 in Chinese, 1 in Chinese, 1 in Chinese) and 11 in accordance with the inclusion criteria. Diagnostic value of mean caloric duration for 24 hours in SBIs: the aggregate sensitivity and specificity of SBIs were 0.75 and 0.80, respectively. The sum sensitivity and specificity of AUC were 0.48 and 0.54, respectively, and the sum sensitivity and specificity of 0.484A were 0.30 and 0.30, respectively. Diagnostic value of mean caloric duration for SBIs in 48h the aggregate sensitivity and specificity of SBIs were 0.86 and 0.63, respectively. The aggregate sensitivity and specificity were 0.54 and 0.466, respectively. The sum sensitivity and specificity of SBIs were 0.47 and 0.12.3, respectively. Diagnostic value of 48h for SBIs the aggregate sensitivity and specificity of WBC were 0.83 and 0.55AUC, 0.816AUC, 0.69 and 0.34, respectively, and the sensitivity and specificity of WBC were 0.81 and 0.29, respectively. Conclusion: the sensitivity and specificity of WBC are 0.87 and 0.40.Conclusion: the sensitivity and specificity of WBC are 0.87 and 0.40.Conclusion: the sensitivity and specificity of WBC are 0.87 and 0.40.Conclusion: the sensitivity and specificity of WBC are 0.87 and 0.40 respectively. The diagnostic value of SBIs in children with fever, Febrile 24 had higher specificity for PCT and 24-48 h for PCT.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R446.5

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