本文關(guān)鍵詞： 組織血氧飽和度 無(wú)創(chuàng)檢測(cè) 可見(jiàn)近紅外光譜 回歸預(yù)測(cè)　出處：《浙江大學(xué)》2015年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：血氧飽和度指血液中氧合血紅蛋白的含量占血紅蛋白總量的百分比,人體組織血氧飽和度是指局部組織中各種微血管中血液的氧飽和度綜合值,反映局部組織的氧合情況。無(wú)損、持續(xù)和快速監(jiān)測(cè)人體組織中血氧飽和度具有十分重要的臨床意義。本文在綜述了血氧飽和度檢測(cè)方法和光譜分析技術(shù)原理、發(fā)展現(xiàn)狀的基礎(chǔ)上,根據(jù)人體組織中血紅蛋白的光學(xué)特性和光譜分析技術(shù)的特點(diǎn),提出了一種利用可見(jiàn)近紅外光譜分析技術(shù)的無(wú)創(chuàng)檢測(cè)組織血氧飽和度的方法。主要研究工作內(nèi)容如下：(1)根據(jù)氧合血紅蛋白與脫氧血紅蛋白在200～1000nm波段的吸收光譜特點(diǎn),提出了一種利用可見(jiàn)近紅外光譜技術(shù)檢測(cè)血氧飽和度的方法,通過(guò)數(shù)據(jù)處理與建模手段對(duì)溶液中血紅蛋白的血氧飽和度進(jìn)行預(yù)測(cè),從而可開(kāi)發(fā)成無(wú)創(chuàng)檢測(cè)組織中血液血氧飽和度的方法。(2)建立了血紅蛋白氧合實(shí)驗(yàn)系統(tǒng)并優(yōu)化了系統(tǒng)參數(shù),利用血紅蛋白氧合模型對(duì)上述可見(jiàn)近紅外光譜方法預(yù)測(cè)的血氧飽和度進(jìn)行了定標(biāo),并分析了其中的影響因素。通過(guò)建立的可見(jiàn)近紅外光譜回歸模型就能對(duì)預(yù)測(cè)集樣本的血氧飽和度進(jìn)行預(yù)測(cè)。(3)將所提出的方法應(yīng)用于人體血液中的血氧飽和度檢測(cè)。完成了血液紅細(xì)胞氧合實(shí)驗(yàn)系統(tǒng)設(shè)計(jì)并優(yōu)化了系統(tǒng)參數(shù),在血液紅細(xì)胞氧合體系中對(duì)上述可見(jiàn)近紅外光譜方法預(yù)測(cè)的血氧飽和度進(jìn)行了定標(biāo),并且對(duì)血液濃度等影響因素進(jìn)行了分析。建立可見(jiàn)近紅外光譜回歸模型,能夠?qū)︻A(yù)測(cè)集樣本的血氧飽和度進(jìn)行預(yù)測(cè),并對(duì)預(yù)測(cè)結(jié)果進(jìn)行了分析。實(shí)驗(yàn)結(jié)果表明,在檢測(cè)血紅蛋白溶液中血氧飽和度時(shí),該方法對(duì)血氧飽和度的預(yù)測(cè)相對(duì)誤差能保持在6%以?xún)?nèi)；在檢測(cè)人體血液中的血氧飽和度時(shí),大部分樣本點(diǎn)處預(yù)測(cè)相對(duì)誤差在10%以?xún)?nèi)。綜上所述,本文研究的可見(jiàn)近紅外光譜無(wú)損檢測(cè)組織血氧飽和度的方法能夠有效地用透射方式檢測(cè)溶液中的血氧飽和度,可以進(jìn)一步開(kāi)發(fā)設(shè)計(jì)成為人體組織血氧飽和度的無(wú)創(chuàng)檢測(cè)裝置。
[Abstract]:Blood oxygen saturation refers to the percentage of oxygenated hemoglobin in blood to the total hemoglobin, and oxygen saturation in human tissue is the comprehensive value of blood oxygen saturation in various microvessels in local tissues. Continuous and rapid monitoring of blood oxygen saturation in human tissues is of great clinical significance in reflecting the oxygenation of local tissues. This article reviews the measurement methods of blood oxygen saturation and the principle of spectral analysis. Based on the present situation, according to the optical properties of hemoglobin in human tissues and the characteristics of spectral analysis technology. A noninvasive method for detecting blood oxygen saturation of tissues using visible near infrared spectroscopy (VNIR) is proposed. The main contents of this study are as follows: 1). According to the absorption spectra of oxygenated hemoglobin and deoxyhemoglobin at 1000nm. A method of detecting oxygen saturation of blood by using visible near infrared spectroscopy is proposed. The oxygen saturation of hemoglobin in solution is predicted by means of data processing and modeling. Therefore, a non-invasive method for detecting blood oxygen saturation in tissues was developed.) the hemoglobin oxygenation experimental system was established and the system parameters were optimized. Hemoglobin oxygenation model was used to calibrate the oxygen saturation predicted by the visible near infrared spectroscopy. The influence factors were analyzed. By using the VNIR regression model, the oxygen saturation of the predicted sample can be predicted. The proposed method is applied to the measurement of blood oxygen saturation in human blood, and the system parameters of the blood red blood cell oxygenation experiment system are designed and optimized. The oxygen saturation predicted by the visible near infrared spectroscopy was calibrated in the blood erythrocyte oxygenation system, and the influence factors such as blood concentration were analyzed. The visible near infrared spectroscopy regression model was established. It can predict the oxygen saturation of the predicted sample and analyze the predicted results. The experimental results show that the oxygen saturation in hemoglobin solution is detected. The relative error of the method for predicting oxygen saturation can be kept within 6%. In the detection of oxygen saturation in human blood, the relative error of prediction at most of the sample points is less than 10%. In this paper, the method of non-destructive detection of tissue oxygen saturation by near infrared spectroscopy can effectively detect the oxygen saturation in solution by transmission method. It can be further developed and designed as a non-invasive measurement device for blood oxygen saturation in human tissues.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：R446.1;O433.4

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