本文關(guān)鍵詞：兩步法在數(shù)量性狀關(guān)聯(lián)分析中的應(yīng)用　出處：《黑龍江大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 兩步法 數(shù)量性狀 關(guān)聯(lián)分析 群體分層

【摘要】：全基因組關(guān)聯(lián)研究是指在全基因組層面上,利用大量的樣本,對基因與疾病的關(guān)聯(lián)性進行反復(fù)驗證的一種研究.作為一種發(fā)現(xiàn)復(fù)雜疾病易感基因的重要工具,全基因組關(guān)聯(lián)研究已經(jīng)幫助許多研究人員成功的找到了數(shù)千個與多種疾病相關(guān)聯(lián)的位點.相對于一步法而言,合理的兩步法能夠大幅度的降低測序工作量和費用.兩步法使用同一個樣本,并且在兩步中分別使用兩個不同的統(tǒng)計量.首先,我們對樣本中大量的候選位點進行篩選,選出一些顯著的位點.然后,對上一步篩選出來的那些位點進行進一步的檢驗,確定與目標(biāo)性狀相關(guān)聯(lián)的基因位點.當(dāng)前,兩步法成為全基因組關(guān)聯(lián)性研究中一種常見的方法.在家庭數(shù)據(jù)中,關(guān)聯(lián)信息可以被劃分為家庭之間的信息和家庭內(nèi)部的信息.在第一步中,利用家庭之間的信息來篩選標(biāo)記位點;在第二步中,利用家庭內(nèi)部的信息對已選擇的標(biāo)記位點進行關(guān)聯(lián)分析.本文對已有的兩步法進行了深入的研究,并且提出了一種新的兩步法.新方法基于核心家庭數(shù)據(jù),利用兩個不相關(guān)的統(tǒng)計量對基因位點進行篩選和檢驗,之后進行模擬研究,以判斷新方法的第一類錯誤率和功效,并與其他方法進行比較.
[Abstract]:A genome-wide association study refers to the whole genome level, using a large number of samples, a study of repeated verification of relevance to gene and disease. As an important tool for complex disease susceptibility gene, genome-wide association studies have helped many researchers successfully found associated with many thousands of the disease locus. Compared with one step, two step reasonable can greatly reduce the workload and cost. The two step was to use the same sample, and respectively using two different statistics in two steps. First, we screened for candidate loci of large samples, select some significant sites then. Further, the inspection of those sites were screened out one step, determine the relevant and objective traits associated loci. At present, two step into genome-wide association studies A common method. In the family data, related information can be divided into family between information and information within the family. In the first step, to screening marker loci between families using information; in the second step, association analysis of marker loci have been selected by family information. In this paper, two step on the in-depth study, and puts forward a new two step method. The new method based on the core of family data, screening and testing of gene loci using two statistics are not related, after simulation study, the first class error rate and efficacy judgment method, and compared with other methods.

【學(xué)位授予單位】：黑龍江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R440

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相關(guān)期刊論文 前1條

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本文編號：1399011