本文關(guān)鍵詞：同種抗體特異性不明確的81名患者血清學(xué)特征分析及紅細(xì)胞輸注效果評(píng)價(jià)　出處：《中國(guó)輸血雜志》2016年12期 　論文類(lèi)型：期刊論文

  更多相關(guān)文章： 非特異抗體 血清學(xué)特征 輸注效果

【摘要】：目的對(duì)存在特異性不明確的同種抗體患者,通過(guò)分析血清學(xué)特征及評(píng)估紅細(xì)胞輸注效果,評(píng)價(jià)配血方法的安全性。方法回顧性分析本院2013-2014年度不規(guī)則抗體篩查陽(yáng)性且血清學(xué)方法無(wú)法明確抗體特異性的患者139例,并應(yīng)用臨床輸血智能管理與評(píng)估系統(tǒng)對(duì)81例輸注紅細(xì)胞的患者進(jìn)行效果評(píng)價(jià)。結(jié)果 139例患者中,抗體類(lèi)型分5種,效價(jià)低、活性弱抗體占多數(shù)。139例患者中紅細(xì)胞輸注81例,輸注紅細(xì)胞114次。其中輸注有效率77.2%;部分有效率22.8%;輸注無(wú)效率0%。不同類(lèi)型抗體輸注有效率與部分有效率無(wú)顯著性差異(P0.05)。81例輸注紅細(xì)胞患者中,男性34例,有輸血史者19例(55.9%);女性47例,有輸血史者43例(91.5%)。所有輸血病例均無(wú)溶血性輸血反應(yīng)發(fā)生。結(jié)論紅細(xì)胞輸注前,不規(guī)則抗體篩查是必要的,尤應(yīng)注意有輸血史病例。即使血清學(xué)方法無(wú)法明確抗體特異性,必須同時(shí)用鹽水法和微柱凝膠法做交叉配血試驗(yàn),選擇相合的血液輸注。避免紅細(xì)胞輸注無(wú)效、輸血不良反應(yīng)的發(fā)生,節(jié)約血液資源,提高輸血安全。
[Abstract]:The purpose of the same patient specific antibodies are not clear, through the analysis and evaluation of effectiveness of red blood cell transfusion serological characteristics, safety evaluation of matching methods. Methods a retrospective analysis of our hospital 2013-2014 irregular antibody screening positive and serological methods is not clear and specific antibodies in patients with 139 cases, and the clinical application of blood transfusion intelligent management and the evaluation system of 81 cases of red blood cell transfusion patients were evaluated. Results in 139 patients, type 5 antibody titer, low activity, weak antibodies accounted for the majority of.139 patients in 81 cases of red blood cell transfusion, infusion of red blood cells 114 times. The infusion rate was 77.2%; effective part 22.8%; transfusionrefractoriness rate of 0%. of different types of antibody infusion efficiency and efficiency have no significant difference (P0.05).81 cases of red blood cell transfusion patients, 34 cases were male, 19 cases had history of blood transfusion (55.9%); 47 cases were female, has a history of blood transfusion 43 cases (91.5%). All cases had no blood transfusion hemolytic transfusion reactions. Conclusion the red cell infusion, irregular antibody screening is necessary, especially should pay attention to the history of blood transfusion cases. Even serological methods can not clear the antibody specificity, must at the same time with saline water method and microcolumn gel cross match test choose, matched blood transfusions. Red blood cell transfusion to avoid invalid, the occurrence of adverse transfusion reactions, save blood resources, improve the safety of blood transfusion.

【作者單位】： 中國(guó)人民解放軍總醫(yī)院輸血科;
【基金】：“十三五”全軍后勤科研項(xiàng)目子課題(BWS16J006)
【分類(lèi)號(hào)】：R457.11
【正文快照】： 由于輸血后或妊娠后患者具有同種抗體免疫的潛在風(fēng)險(xiǎn),有報(bào)道長(zhǎng)期輸血的患者,14%-50%的個(gè)體可能產(chǎn)生同種免疫反應(yīng)。血清學(xué)檢測(cè)若未能發(fā)現(xiàn)抗體存在,輸血后誘導(dǎo)潛在抗體與相應(yīng)抗原發(fā)生免疫反應(yīng),出現(xiàn)紅細(xì)胞輸注無(wú)效、遲發(fā)型溶血性輸血反應(yīng),并且會(huì)加重原發(fā)病甚至威脅生命。所以應(yīng)重

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本文編號(hào)：1397292