本文關(guān)鍵詞：IVIM-DWI成像鑒別兔軟組織VX2腫瘤凝固性壞死價(jià)值的探討　出處：《中華腫瘤防治雜志》2016年09期 　論文類(lèi)型：期刊論文

  更多相關(guān)文章： 兔 VX腫瘤 凝固性壞死 磁共振成像 彌散加權(quán)成像 灌注 體素內(nèi)不相干運(yùn)動(dòng)

【摘要】：目的確定軟組織腫瘤內(nèi)有無(wú)壞死區(qū)對(duì)其生物學(xué)特性及治療效果的評(píng)估都有著重要的意義。腫瘤內(nèi)的壞死可為液化性壞死或凝固性壞死,對(duì)后者的MRI研究少見(jiàn)。本研究探討體素內(nèi)不相干運(yùn)動(dòng)彌散加權(quán)成像(intravoxel incoherent motion diffusion-weighted imaging,IVIM-DWI)在鑒別兔軟組織VX2腫瘤中存活組織與凝固性壞死組織的價(jià)值。方法在15只新西蘭兔左側(cè)大腿肌肉內(nèi)接種VX2腫瘤,3周后對(duì)其行動(dòng)態(tài)對(duì)比劑增強(qiáng)磁共振成像(dynamic contrastenhanced MR imaging,DCE-MRI)和IVIM-DWI成像檢查(7個(gè)b值,0~800s/mm2)。采用MITK Diffusion軟件對(duì)IVIM-DWI數(shù)據(jù)進(jìn)行處理,形成灌注分?jǐn)?shù)(f值)和真性彌散系數(shù)(D值)的參數(shù)圖。MRI檢查完畢后處死實(shí)驗(yàn)用兔獲取腫瘤標(biāo)本,在軸位方向上切片,獲取與MR軸位圖像相對(duì)應(yīng)的大體標(biāo)本斷層組織厚片,并以其為參照,并結(jié)合增強(qiáng)早期DCE-MRI在標(biāo)本對(duì)應(yīng)層面的感興趣區(qū)(region of interest,ROI)測(cè)量存活腫瘤組織、凝固性壞死組織的f值和D值。分別采用Wilcoxon秩和檢驗(yàn)和獨(dú)立樣本t檢驗(yàn)比較存活腫瘤組織與凝固性壞死組織之間D值和f值的差異。結(jié)果所有實(shí)驗(yàn)用兔的VX2腫瘤均種植成功。共選取51個(gè)ROI,其中存活腫瘤組織34個(gè),凝固性壞死組織17個(gè)。存活腫瘤組織和凝固性壞死組織的f值分別為(7.995±2.867)%和(5.918±2.709)%,t=2.484,P=0.016。存活腫瘤組織與凝固性壞死組織的D值分別為(1.110±0.110)×10-3和(1.132±0.208)×10-3 mm2/s,Z=0.100,P=0.920。結(jié)論由IVIM-DWI所生成的f值能很好地鑒別兔軟組織VX2腫瘤中的存活腫瘤組織與凝固性壞死組織,而D值不能鑒別。
[Abstract]:Objective to determine whether there are necrotic areas in soft tissue tumors and to evaluate their biological characteristics and therapeutic effects. Necrosis in soft tissue tumors can be liquefaction necrosis or coagulative necrosis. MRI studies of the latter are rare. In this study, diffusion-weighted imaging of incoherent motion in voxels (. Intravoxel incoherent motion diffusion-weighted imaging. The value of IVIM-DWI in differentiating survival tissue from coagulant necrotic tissue in rabbit soft tissue VX2 tumor. Methods VX2 tumor was inoculated into the left thigh muscle of 15 New Zealand rabbits. After 3 weeks, dynamic contrast agent enhanced dynamic contrastenhanced Mr imaging was performed. DCE-MRI) and IVIM-DWI imaging (7 b values). Using MITK Diffusion software to process IVIM-DWI data. Formation of perfusion fraction (f) and true diffusion coefficient (D). After MRI examination, the rabbits were killed to obtain tumor specimens, and sections were made in the axial direction. The thick sections of the gross specimens corresponding to Mr axial images were obtained and used as a reference. The survival tumor tissue was measured by using the region of interest ROI on the corresponding plane of specimen with enhanced early DCE-MRI. Wilcoxon rank sum test and independent sample t test were used to compare the difference of D value and f value between viable tumor tissue and coagulative necrotic tissue. All the VX2 tumors were successfully implanted in rabbits. 51 ROI were selected. 34 of them survived tumor tissue. There were 17 coagulant necrotic tissues. The f values of surviving tumor tissues and coagulative necrotic tissues were 7.995 鹵2.867% and 5.918 鹵2.709%, respectively. The D values of survival tumor tissue and coagulative necrosis tissue were 1.110 鹵0.110 脳 10-3 and 1.132 鹵0.208, respectively. 脳 10-3 mm2/s. Conclusion the f value generated by IVIM-DWI can distinguish survival tumor tissue from coagulant necrotic tissue in rabbit soft tissue VX2 tumor. The D value could not be distinguished.
【作者單位】： 中山大學(xué)附屬第一醫(yī)院醫(yī)學(xué)影像科;中山市中醫(yī)院放射科;
【基金】：廣東省科技計(jì)劃(2012B031800071)
【分類(lèi)號(hào)】：R445.2;R738.6
【正文快照】： 中華腫瘤防治雜志,2016,23(9):582-586※在本研究中與第一作者貢獻(xiàn)相同slices corresponding to the axial MR images.The values of D and f were measured for the regions of interest(ROIs)ofviable tumor tissue and coagulation necrosis within the tumors,which were

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