本文關鍵詞：血流感染假絲酵母菌菌種構成及其藥物敏感性　出處：《中國感染控制雜志》2016年03期 　論文類型：期刊論文

  更多相關文章： 假絲酵母菌 近平滑假絲酵母菌 抗真菌藥物 血流感染 藥敏試驗 抗藥性 微生物 耐藥性 醫(yī)院感染

【摘要】：目的分析某院假絲酵母菌血流感染菌種構成及其對抗真菌藥物的敏感性,為臨床預防和治療假絲酵母菌血流感染提供依據。方法回顧性分析2009—2013年該院臨床科室送檢血標本中檢出的假絲酵母菌,并對假絲酵母菌血流感染的高危因素進行分析。結果 2009—2013年42例患者血標本分離假絲酵母菌42株,以近平滑假絲酵母菌為主(20株,47.62%),其次為白假絲酵母菌(16株,38.10%)、熱帶假絲酵母菌(4株,9.52%)、光滑假絲酵母菌(2株,4.76%)。來源科室主要為:急診監(jiān)護病房(EICU,11株)、泌尿外科(9株)、心胸外科(8株)等。37例(占88.10%)患者靜脈導管與血標本培養(yǎng)出相同的假絲酵母菌,留置靜脈導管至血培養(yǎng)陽性和導管培養(yǎng)陽性的平均時間分別為31.47 d和33.18 d;導管和血培養(yǎng)陽性比例隨著置管時間的延長均呈上升趨勢(均P0.001)。檢出的假絲酵母菌對氟康唑、伏立康唑的敏感率均為75.00%~100.00%,對兩性霉素B的敏感率均為100.00%;而不同菌種對伊曲康唑的敏感率存在較大差異(0~87.50%)。結論該院假絲酵母菌血流感染菌株以近平滑假絲酵母菌為主,且與靜脈導管的使用有關,其對氟康唑、兩性霉素B、伏立康唑的敏感性均較高。
[Abstract]:Objective: analysis of Candida bloodstream infection in species composition and their sensitivity to antifungal agents, for clinical prevention and treatment of Candida yeast provides the basis for blood infection. Methods Retrospective analysis of Candida albicans were detected in 2009 - 2013 the hospital clinical departments of inspection of blood samples, and the risk factors of Candida bloodstream infection analysis from 2009 to 2013. Results 42 patients blood samples were isolated 42 strains of Candida, nearly smooth Candida dominated (20 strains, 47.62%), followed by Candida albicans (16 strains, 38.10%), tropical Candida yeast strains (4 strains, 9.52%), Candida glabrata (2 strains. 4.76%). Department for emergency intensive care unit (EICU, 11 strains (9 strains), Department of Urology), cardiothoracic surgery (8 strains),.37 (88.10% cases) of patients with venous catheter and blood samples were cultured Candida same, indwelling venous catheter and blood culture positive The average time of culture positive and catheter were 31.47 D and 33.18 D; and the proportion of positive blood culture catheter with prolonged catheter were increased (P0.001). The detection of Candida albicans to fluconazole, voriconazole susceptibility rate was 75.00%~100.00%, the sensitive rate of amphotericin B was 100% there is a big difference; and different strains of itraconazole susceptibility rate (0~87.50%). Conclusions the Candida bloodstream infection by Candida parapsilosis strains, and the use of intravenous catheter related to fluconazole, amphotericin B and voriconazole were more sensitive.

【作者單位】： 廣州軍區(qū)武漢總醫(yī)院;
【分類號】：R446.5
【正文快照】： azole are all high.[Chin J Infect Control,2016,15(3):172-175]假絲酵母菌常定植在健康人的口腔、皮膚和胃腸道等部位,通常情況下并不致病[1]。但自1979年以來,假絲酵母菌從血液中檢出的比例不斷增加,已成為血流感染的主要病原菌之一,免疫力受損及患有嚴重基礎疾病的住院患

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