【摘要】：隨著現(xiàn)代科技的發(fā)展，，微納米粉體技術(shù)的應(yīng)用涉及到食品、醫(yī)藥、化工、生物工程等諸多領(lǐng)域。微納米粉體技術(shù)的研究涉及到微納米粉體的制備技術(shù)、顆粒特性的描述與表征技術(shù)、顆粒表面改性技術(shù)等。其中，微納米粉體制備技術(shù)作為微納米粉體技術(shù)研究與應(yīng)用的基礎(chǔ)和前提顯得尤為重要。同時(shí)，在生物醫(yī)藥領(lǐng)域，肺部吸入給藥方式以非侵入方式傳遞到肺部，產(chǎn)生局部或全身治療的作用，逐漸成為治療哮喘的有效方式。當(dāng)肺吸入藥物粉體粒徑為1~5μm時(shí)，藥物作用最為有效。 本文針對(duì)生物肺吸入給藥微納藥物粉體制備問題，分析研究微納米粉體制備方法，提出采用壓電驅(qū)動(dòng)噴霧干燥方法制備生物微納藥物粉體。通過對(duì)技術(shù)方案的比較設(shè)計(jì)，采用縱徑復(fù)合壓電驅(qū)動(dòng)方案進(jìn)行料液的微噴霧化，并提出壓電復(fù)合驅(qū)動(dòng)微噴霧化干燥的整體技術(shù)方案。依據(jù)方案的研究，分析壓電微噴霧化干燥工作過程，構(gòu)建了微噴霧化數(shù)學(xué)模型，在數(shù)學(xué)模型的基礎(chǔ)上，對(duì)生物微納粉體噴霧干燥裝置的關(guān)鍵結(jié)構(gòu)霧化器的液腔結(jié)構(gòu)尺寸、壓電驅(qū)動(dòng)材料結(jié)構(gòu)以及驅(qū)動(dòng)參數(shù)進(jìn)行設(shè)計(jì)計(jì)算。 利用有限元分析軟件對(duì)壓電噴霧驅(qū)動(dòng)過程進(jìn)行壓電仿真分析，模擬了液滴的形成過程，并利用構(gòu)建的實(shí)驗(yàn)裝置對(duì)壓電微噴霧化干燥系統(tǒng)進(jìn)行了粉體噴霧干燥實(shí)驗(yàn)研究。實(shí)驗(yàn)結(jié)果表明，縱徑復(fù)合壓電驅(qū)動(dòng)噴霧干燥方式獲得干燥粉體粒徑分布為3~5μm，滿足生物微納藥物粉體有效吸收范圍的要求，且粒徑分布均勻，粉體分散性良好。
[Abstract]:With the development of modern science and technology, the application of micro-nano-powder technology involves many fields such as food, medicine, chemical industry, bio-engineering and so on. The research of micro-nano-powder technology involves the preparation of micro-nano-powder, the description and characterization of particle characteristics, the surface modification of particles and so on. Among them, the preparation technology of micro-nano-meter powder is very important as the foundation and premise of the research and application of micro-nano-powder technology. At the same time, in the field of biomedicine, lung inhalation drug delivery to the lungs in a non-invasive manner, resulting in local or systemic treatment, has gradually become an effective way to treat asthma. When the particle size of lung inhaled drug powder was 1 ~ 5 渭 m, the drug effect was the most effective. In this paper, the preparation method of micro-nano-drug powder by bio-lung inhalation was analyzed and studied, and a piezoelectric-driven spray-drying method was proposed for the preparation of bio-nano-drug powder. Through the comparison and design of the technical scheme, the longitudinal-diameter composite piezoelectric driving scheme is adopted to spray the liquid and the whole technical scheme of the micro-spray drying with piezoelectric composite drive is put forward. According to the study of the scheme, the working process of piezoelectric micro-spray atomization drying is analyzed, and the mathematical model of micro-spray atomization is constructed. On the basis of the mathematical model, the liquid cavity structure size of the atomizer, which is the key structure of the bio-micro-nano powder spray drying device, is studied. The piezoelectric driving material structure and driving parameters are designed and calculated. The piezoelectric spray driving process was simulated by finite element analysis software, and the droplet formation process was simulated. The powder spray drying system of piezoelectric micro-spray atomization drying system was studied by using the built experimental device. The experimental results show that the particle size distribution of the powder is 3 ~ 5 渭 m, which meets the requirements of the effective absorption range of the bio-nano-drug powder, and the particle size distribution is uniform and the powder dispersion is good.
【學(xué)位授予單位】：蘇州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：TB4

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本文編號(hào)：2445344