本文選題：高強(qiáng)度聚焦超聲 + 組織損傷��； 參考：《南京大學(xué)》2017年碩士論文

【摘要】：高強(qiáng)度聚焦超聲(HIFU)在腫瘤治療的臨床應(yīng)用上取得了飛速進(jìn)展,而HIFU換能器的掃描模式對(duì)HIFU治療的熱損傷形成有著重要的影響。本文通過(guò)理論模擬和實(shí)驗(yàn)探究,研究HIFU在采用螺旋線路徑的連續(xù)掃描模式下溫度場(chǎng)的分布和組織損傷形成情況。理論方面,建立了基于KZK方程和Pennes生物傳熱方程的聲熱耦合模型以及基于熱劑量的損傷形成模型,定量預(yù)測(cè)HIFU治療的溫度場(chǎng)分布和損傷形成狀況。實(shí)驗(yàn)方面,進(jìn)行了以凝膠和離體牛肝組織樣品的HIFU實(shí)驗(yàn),設(shè)定掃描速度和螺旋路徑的柵格間距為控制變量來(lái)對(duì)比損傷情況,分析了柵格間距和掃描速度對(duì)溫度場(chǎng)分布,損傷形狀以及治療效率的影響。研究結(jié)果表明,采用螺旋路徑的連續(xù)掃描模式,可以充分發(fā)揮熱擴(kuò)散效應(yīng)的積極作用,有效產(chǎn)生完全覆蓋治療區(qū)域的均勻性損傷。選擇柵格間距較小的螺旋路徑,更能發(fā)揮熱擴(kuò)散的作用力,更容易實(shí)現(xiàn)損傷對(duì)治療區(qū)域的完全覆蓋,獲得更高的治療效率。本文的研究工作對(duì)于HIFU治療安全性和治療效率的提高具有指導(dǎo)意義。
[Abstract]:High intensity focused ultrasound (HIFU) has made rapid progress in the clinical application of tumor therapy, and the scanning mode of HIFU transducer has an important effect on the formation of thermal injury in HIFU treatment. In this paper, the distribution of temperature field and the formation of tissue damage in HIFU under the continuous scanning mode with helical path are studied by theoretical simulation and experimental investigation. In theory, the acoustothermal coupling model based on KZK equation and Pennes bio-heat transfer equation and the damage formation model based on thermal dose were established to quantitatively predict the temperature field distribution and injury formation of HIFU therapy. In the aspect of experiment, the HIFU experiments of gel and in vitro bovine liver tissue samples were carried out. The scanning speed and the space between the helical paths were set as the control variables to compare the damage, and the distribution of the temperature field between the grid spacing and the scanning velocity was analyzed. The effects of injury shape and therapeutic efficiency. The results show that continuous scanning mode with spiral path can give full play to the positive effect of thermal diffusion and effectively produce uniform damage covering the treatment area completely. The helical path with small grid spacing can play the role of thermal diffusion more easily to achieve the complete coverage of the treatment area and obtain higher therapeutic efficiency. The research in this paper is of guiding significance for the improvement of safety and efficiency of HIFU treatment.
【學(xué)位授予單位】：南京大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R454.3;TB559
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本文編號(hào)：1871984