【摘要】：環(huán)氧蟲(chóng)啶是華東理工大學(xué)發(fā)現(xiàn)的具有自主知識(shí)產(chǎn)權(quán)的、結(jié)構(gòu)新穎的新煙堿類殺蟲(chóng)劑,對(duì)吡蟲(chóng)啉的抗性害蟲(chóng)具有顯著活性,而且對(duì)鱗翅目害蟲(chóng)也具有較好的防治效果。目前環(huán)氧蟲(chóng)啶正在產(chǎn)業(yè)開(kāi)發(fā)中,確定并優(yōu)化工藝路線、降低生產(chǎn)成本是環(huán)氧蟲(chóng)啶實(shí)現(xiàn)產(chǎn)業(yè)化并最終走向市場(chǎng)的關(guān)鍵。 本論文的目的是對(duì)環(huán)氧蟲(chóng)啶的合成路線進(jìn)行分析,確定其工藝路線并進(jìn)行優(yōu)化,達(dá)到適合工業(yè)化生產(chǎn)的要求。在環(huán)氧蟲(chóng)啶專利合成路線的基礎(chǔ)上,根據(jù)其結(jié)構(gòu)特點(diǎn),設(shè)計(jì)三條路線并進(jìn)行評(píng)估,確定了一條可行的工藝路線：以偏二氯乙烯為起始原料,經(jīng)過(guò)硝化、環(huán)合、縮合得到硝基亞甲基中間體。此中間體與2,5-二甲氧基四氫呋喃經(jīng)水解得到的丁二醛反應(yīng)、再環(huán)合得到環(huán)氧蟲(chóng)啶。 本論文對(duì)確定的路線中每步反應(yīng)進(jìn)行合成條件及后處理的優(yōu)化,討論了各種因素對(duì)反應(yīng)的影響,從中得到了合成環(huán)氧蟲(chóng)啶的較佳工藝條件。成本由原來(lái)的169萬(wàn)元/噸下降到約87萬(wàn)元／噸。各步反應(yīng)條件溫和,操作簡(jiǎn)單,避免了甲硫醇的排放及過(guò)量乙二胺的使用,是一條更加綠色環(huán)保、具有工業(yè)化開(kāi)發(fā)前景的路線。
[Abstract]:Epoxidin is a new nicotinic insecticide with its own intellectual property rights and novel structure, which has remarkable activity against imidacloprid pests and has good control effect on Lepidoptera pests. At present, epoxidin is in the process of industrial development. To determine and optimize the technological route and reduce the production cost is the key to realize the industrialization of epoxidin and finally to enter the market. The purpose of this paper is to analyze the synthetic route of epoxidin, determine its technological process and optimize it to meet the requirements of industrial production. Based on the synthetic route of epoxide patent, according to its structural characteristics, three routes were designed and evaluated, and a feasible technological route was determined: using vinylidene chloride as the starting material, nitration, cyclization, nitration and cyclization. The intermediate of nitromethylene was obtained by condensation. The intermediate reacts with 2-dimethoxytetrahydrofuran to hydrolyze succinaldehyde and cyclization to obtain epoxide. In this paper, the synthesis conditions and post-treatment of each reaction in the determined route were optimized, and the effects of various factors on the reaction were discussed, from which the better technological conditions for the synthesis of cycloprozidine were obtained. The cost dropped from 1.69 million yuan / ton to about 870000 yuan / ton. The reaction conditions are mild, the operation is simple, the emission of methionol and the use of excessive ethylenediamine are avoided, which is a more green and environmentally friendly route with the prospect of industrial development.
【學(xué)位授予單位】：華東理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：TQ453.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王彥明;姚曉龍;王建明;;乙二胺合成及分離工藝進(jìn)展[J];廣州化工;2010年10期

2 賀啟環(huán),羅欣,畢濤巍,王詠梅;甲硫醇高效降解菌的篩選[J];化工環(huán)保;2004年S1期

3 金萬(wàn)祥;李敢;;相轉(zhuǎn)移催化合成1-(2,4-二氯苯基)-2-(1-咪唑基)-乙醇的研究[J];化學(xué)世界;2011年09期

4 范元峰;陳潔;蒙燕婕;;淺談殺蟲(chóng)劑吡蟲(chóng)啉的生產(chǎn)工藝改進(jìn)[J];科技風(fēng);2011年10期

5 牛星鋼;;甲硫醇泄漏風(fēng)險(xiǎn)控制技術(shù)[J];中國(guó)安全生產(chǎn)科學(xué)技術(shù);2010年03期

6 王衛(wèi)東;齊國(guó)慶;黃其成;高陽(yáng)光;段鴻業(yè);;化學(xué)填料塔脫除惡臭氣體工藝研究[J];石油化工應(yīng)用;2010年09期

7 程霞 ,亦冰;第二代新煙堿類殺蟲(chóng)劑噻蟲(chóng)嗪的開(kāi)發(fā)[J];世界農(nóng)藥;2001年04期

8 張亦冰;新內(nèi)吸殺蟲(chóng)劑——呋蟲(chóng)胺[J];世界農(nóng)藥;2003年05期

9 程志明;;我國(guó)吡蟲(chóng)啉工業(yè)化合成路線探討[J];世界農(nóng)藥;2011年05期

10 李璐;邵旭升;吳重言;孫琴;李忠;徐曉勇;;殺蟲(chóng)劑哌蟲(chóng)啶合成的工藝優(yōu)化[J];現(xiàn)代農(nóng)藥;2009年02期

，

本文編號(hào)：2133972