本文關(guān)鍵詞：中藥治療阿爾茨海默病的作用特點(diǎn)，，由筆耕文化傳播整理發(fā)布。

中藥治療阿爾茨海默病的作用特點(diǎn)

Action Characteristics of Traditional Chinese Medicine in Treatment of Alzheimer＇s Disease

[1] [2]

LI Lin, ZHANG Lan （Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 1

神經(jīng)變性病教育部重點(diǎn)實(shí)驗(yàn)室 首都醫(yī)科大學(xué)宣武醫(yī)院藥物研究室,北京100053

文章摘要：阿爾茨海默�。ˋD）是一種多因素相關(guān)的復(fù)雜性疾病,目前臨床治療效果不佳.僅針對單靶點(diǎn)或單致病途徑的藥物不易取得好的療效.另一個重要原因是干預(yù)時機(jī)太晚,當(dāng)診斷出癡呆時患者腦內(nèi)已有大量神經(jīng)元死亡.因此,應(yīng)當(dāng)針對多靶點(diǎn)、多途徑治療,同時將治療時機(jī)提前到癡呆發(fā)生前,才有可能在AD的藥物干預(yù)領(lǐng)域?qū)崿F(xiàn)新的突破.本文綜述了作者近十多年來在中藥治療AD方面的研究工作,包括中藥新復(fù)方參烏膠囊、中藥提取物何首烏二苯乙烯苷、山茱萸環(huán)烯醚萜苷、淫羊藿黃酮和淫羊藿苷對多種擬AD動物模型和細(xì)胞模型的影響及其作用機(jī)制.這些中藥的特點(diǎn)是作用在AD復(fù)雜發(fā)病機(jī)制的多靶點(diǎn)和多途徑,尤其是具有神經(jīng)保護(hù)和神經(jīng)營養(yǎng)/再生作用,且對線粒體和突觸具有明顯的保護(hù)作用,可望用于AD的早期干預(yù)或輕度認(rèn)知障礙期（MCI）的治療,從而阻止或延緩癡呆的發(fā)生與進(jìn)程.

Abstr：Alzheimer＇s disease （AD） is a multifactorial complex disease. The failure of recent development of AD therapeutic agents in clinical trials is mainly due to their single-target or single-pathogenic pathway effect. The poor clinical outcome of AD treatment is also due to the late intervention. A large number of neuronal death has already happened at the time of diagnosis. Aiming at the complex diseases with unclear causes and many related factors, the multi-target and multi-link treatment characteristics of traditional Chinese medicine have advantages over the single target treatment. Therefore, we have committed to the research of traditional Chinese medicine in treatment of AD and the development of new drugs since 1995. In this paper, our research results for more than 10 years were reviewed. Our study showed that traditional Chinese medicine formula （Shenwu capsule） and single herb extracts （Tetrahydroxy-stilbene glucoside, Cornel iridoid glycoside, Epimedium flavone and Icariin） could act on the complex pathogenesis of AID at multi-targets and multi-pathways, especially have both neuroprotective and neurotrophic/regenerative effects, and protect mitochondria and synapses, thus have significant features and advantages for the treatment of AD.

文章關(guān)鍵詞：

Keyword：:Alzheimer＇s disease, therapeutics, traditional Chinese medicine, Shenwu capsule, Tetrahydroxy-stilbene glucoside, Cornel iridoid glycoside, Epimedium flavone, Icariin, animal model, cellular model

課題項(xiàng)目：國家自然科學(xué)基金項(xiàng)目（90709011,30340090,30472184,30500664,30701092,30801526,30973513）; 北京市自然科學(xué)基金項(xiàng)目（7982006,7032013,7063079,7072033,7112061）; 北京市科技計劃項(xiàng)目（951890600,952601800,H01021013011,H020821390190,D0204003000031,D0206001043191）資助

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  本文關(guān)鍵詞：中藥治療阿爾茨海默病的作用特點(diǎn)，由筆耕文化傳播整理發(fā)布。