順氣開郁化痰湯治療反流性食管炎氣郁痰阻證的臨床研究
發(fā)布時(shí)間：2019-06-27 20:31
【摘要】：目的:探討順氣開郁化痰湯治療反流性食管炎氣郁痰阻證的臨床療效及安全性。方法:選取湖南中醫(yī)藥大學(xué)第一附屬醫(yī)院消化內(nèi)科門診、胃鏡室以及社會(huì)上招募的符合反流性食管炎診斷標(biāo)準(zhǔn)的志愿者,共納入60例,其中治療組30例,對(duì)照組30例。分別給予順氣開郁化痰湯和西藥奧美拉唑、多潘立酮片,治療8周,觀察治療前后臨床癥狀及體征的改變,同時(shí)檢測(cè)胃鏡下食管粘膜的變化。結(jié)果:1.治療組與對(duì)照組在治療后總有效率分別為89.6%、71.4%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),表明順氣開郁化痰湯在治療氣郁痰阻證反流性食管炎療效優(yōu)于單純西藥組。2.治療前治療組與對(duì)照組癥狀積分比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05),具有齊同可比性;治療后兩組癥狀積分,與治療前比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05),說明兩組治療均能改善RE氣郁痰阻證患者的臨床癥狀;而治療后治療組與對(duì)照組間比較,差異具有統(tǒng)計(jì)學(xué)意義(P0.05),表明順氣開郁化痰湯在改善RE氣郁痰阻證患者癥狀優(yōu)于對(duì)照組。3.治療組可明顯改善RE氣郁痰阻證患者中醫(yī)癥候,特別對(duì)咽喉如痰梗,情志不暢加重、胸部不適、燒心、反酸、吞咽不利、神情憂郁癥狀療效作用優(yōu)于對(duì)照組。4.治療前治療組與對(duì)照組內(nèi)鏡積分比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05),具有齊同可比性;治療后兩組內(nèi)鏡積分,與治療前比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05),說明兩組治療均能改善RE患者內(nèi)鏡下食管粘膜的表現(xiàn);而治療后治療組與對(duì)照組間比較,差異具有統(tǒng)計(jì)學(xué)意義(P0.05),表明順氣開郁化痰湯在改善RE患者內(nèi)鏡下食管粘膜的表現(xiàn)優(yōu)于對(duì)照組。5.兩組在治療過程中均未出現(xiàn)不良反應(yīng),證明順氣開郁化痰湯治療反流性食管炎氣郁痰阻證安全有效。結(jié)論:順氣開郁化痰湯治療反流性食管炎氣郁痰阻證患者總有效率為89.6%,可明顯改善反流性食管炎氣郁痰阻證患者的中醫(yī)臨床癥狀,改善患者內(nèi)鏡下食管粘膜的表現(xiàn)。
[Abstract]:Objective: to investigate the clinical efficacy and safety of Shunqi Kaiyu Huatan decoction in the treatment of reflux esophagus. Methods: 60 volunteers recruited from the Department of Digestive Medicine, gastroscopy room and society in the first affiliated Hospital of Hunan University of traditional Chinese Medicine were enrolled in 60 volunteers, including 30 cases in the treatment group and 30 cases in the control group. Shunqi Kaiyu Huatan decoction and western medicine omeprazole and domperidone tablets were given respectively for 8 weeks to observe the changes of clinical symptoms and signs before and after treatment, and to detect the changes of esophageal mucosa under gastroscopy. Result: 1. After treatment, the total effective rates of the treatment group and the control group were 89.6% and 71.4%, respectively. there was significant difference between the two groups (P 0.05). The results showed that Shunqi Kaiyu Huatan decoction was superior to the western medicine group in the treatment of reflux esophagitis with syndrome of qi stagnation and phlegm obstruction. 2. Before treatment, there was no significant difference between the treatment group and the control group (P 0.05), and there was no significant difference between the treatment group and the control group (P 0.05). After treatment, the symptom scores of the two groups were significantly different from those before treatment (P 0.05), indicating that the treatment of the two groups could improve the clinical symptoms of RE patients with qi stagnation and phlegm obstruction syndrome. After treatment, there was significant difference between the treatment group and the control group (P 0.05), which indicated that Shunqi Kaiyu Huatan decoction was superior to the control group in improving the symptoms of RE patients with qi stagnation and phlegm obstruction syndrome. The treatment group could significantly improve the TCM symptoms of RE patients with qi stagnation and phlegm obstruction syndrome, especially for throat such as phlegm infarction, aggravation of emotion, chest discomfort, heartburn, acid regurgitation, dysphagia and melancholy. Before treatment, there was no significant difference between the treatment group and the control group (P 0.05), and there was no significant difference between the treatment group and the control group (P 0.05). After treatment, the endoscopic scores of the two groups were significantly different from those before treatment (P 0.05), indicating that the treatment of the two groups could improve the endoscopic esophageal mucosa performance of RE patients. After treatment, the difference between the treatment group and the control group was statistically significant (P 0.05), indicating that Shunqi Kaiyu Huatan decoction was superior to the control group in improving endoscopic esophageal mucosa in patients with RE. 5. There were no adverse reactions in both groups, which proved that Shunqi Kaiyu Huatan decoction was safe and effective in the treatment of reflux esophagus. Conclusion: the total effective rate of Shunqi Kaiyu Huatan decoction in the treatment of reflux esophagus with qi stagnation and phlegm obstruction syndrome is 89.6%, which can obviously improve the clinical symptoms of traditional Chinese medicine (TCM) and the endoscopic esophageal mucosa of patients with reflux esophagitis with qi stagnation and phlegm obstruction syndrome.
【學(xué)位授予單位】：湖南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259
本文編號(hào)：2507126
[Abstract]:Objective: to investigate the clinical efficacy and safety of Shunqi Kaiyu Huatan decoction in the treatment of reflux esophagus. Methods: 60 volunteers recruited from the Department of Digestive Medicine, gastroscopy room and society in the first affiliated Hospital of Hunan University of traditional Chinese Medicine were enrolled in 60 volunteers, including 30 cases in the treatment group and 30 cases in the control group. Shunqi Kaiyu Huatan decoction and western medicine omeprazole and domperidone tablets were given respectively for 8 weeks to observe the changes of clinical symptoms and signs before and after treatment, and to detect the changes of esophageal mucosa under gastroscopy. Result: 1. After treatment, the total effective rates of the treatment group and the control group were 89.6% and 71.4%, respectively. there was significant difference between the two groups (P 0.05). The results showed that Shunqi Kaiyu Huatan decoction was superior to the western medicine group in the treatment of reflux esophagitis with syndrome of qi stagnation and phlegm obstruction. 2. Before treatment, there was no significant difference between the treatment group and the control group (P 0.05), and there was no significant difference between the treatment group and the control group (P 0.05). After treatment, the symptom scores of the two groups were significantly different from those before treatment (P 0.05), indicating that the treatment of the two groups could improve the clinical symptoms of RE patients with qi stagnation and phlegm obstruction syndrome. After treatment, there was significant difference between the treatment group and the control group (P 0.05), which indicated that Shunqi Kaiyu Huatan decoction was superior to the control group in improving the symptoms of RE patients with qi stagnation and phlegm obstruction syndrome. The treatment group could significantly improve the TCM symptoms of RE patients with qi stagnation and phlegm obstruction syndrome, especially for throat such as phlegm infarction, aggravation of emotion, chest discomfort, heartburn, acid regurgitation, dysphagia and melancholy. Before treatment, there was no significant difference between the treatment group and the control group (P 0.05), and there was no significant difference between the treatment group and the control group (P 0.05). After treatment, the endoscopic scores of the two groups were significantly different from those before treatment (P 0.05), indicating that the treatment of the two groups could improve the endoscopic esophageal mucosa performance of RE patients. After treatment, the difference between the treatment group and the control group was statistically significant (P 0.05), indicating that Shunqi Kaiyu Huatan decoction was superior to the control group in improving endoscopic esophageal mucosa in patients with RE. 5. There were no adverse reactions in both groups, which proved that Shunqi Kaiyu Huatan decoction was safe and effective in the treatment of reflux esophagus. Conclusion: the total effective rate of Shunqi Kaiyu Huatan decoction in the treatment of reflux esophagus with qi stagnation and phlegm obstruction syndrome is 89.6%, which can obviously improve the clinical symptoms of traditional Chinese medicine (TCM) and the endoscopic esophageal mucosa of patients with reflux esophagitis with qi stagnation and phlegm obstruction syndrome.
【學(xué)位授予單位】：湖南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259
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相關(guān)碩士學(xué)位論文 前1條
1 李田田;順氣開郁化痰湯治療反流性食管炎氣郁痰阻證的臨床研究[D];湖南中醫(yī)藥大學(xué);2016年
，本文編號(hào)：2507126
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