【摘要】：目的:研究滋陰補(bǔ)陽方序貫療法對排卵障礙性不孕證IUI促排卵周期的臨床療效的觀察。研究滋陰補(bǔ)陽方序貫療法的作用機(jī)制,為中西醫(yī)結(jié)合治療排卵障礙性不孕癥提供依據(jù)。方法:回顧性分析2012年1月-2015年2月在江蘇省中醫(yī)院生殖醫(yī)學(xué)科因排卵障礙不孕癥行夫精人工授精的197個(gè)周期。根據(jù)其治療方案分為兩組。對照組(克羅米芬組)94個(gè)周期,觀察組(克羅米芬+滋陰補(bǔ)陽方序貫療法)103個(gè)周期。觀察兩組的Gn總量,Gn天數(shù),HCG日子宮內(nèi)膜厚度及形態(tài),單卵泡發(fā)育情況,妊娠率與妊娠結(jié)局。結(jié)果:觀察組(中西醫(yī)組)的Gn總量與Gn天數(shù)均顯著低于對照組(西醫(yī)組),P0.05。觀察組的單卵泡發(fā)育的周期數(shù)大于對照組,P0.05,療效有顯著差異。觀察組的妊娠率高于對照組,療效有顯著差異,p0.05。觀察組的治愈率,治愈率與有效率的總和均明顯高于對照組,P0.05。對照組HCG日子宮內(nèi)膜厚度8.73±2.29mm,A型內(nèi)膜數(shù)36,觀察組HCG日子宮內(nèi)膜厚度9.02±2.23mm,A型內(nèi)膜數(shù)39,觀察組HCG日子宮內(nèi)膜厚度與A型內(nèi)膜數(shù)均高于對照組,但P0.05,無顯著療效。觀察組的活嬰率、單胎率高于對照組,但療效無明顯差異,P0.05。結(jié)論:滋陰補(bǔ)陽方序貫療法聯(lián)合西藥促排卵可減少Gn總量與Gn天數(shù),從而減少對卵巢的刺激,促進(jìn)單卵泡發(fā)育。同時(shí),西藥聯(lián)合滋陰補(bǔ)陽方序貫療法,可顯著提高卵泡質(zhì)量與妊娠率。
[Abstract]:Objective: to study the clinical effect of sequential therapy of nourishing yin and tonifying yang on IUI induction cycle of ovulatory disorder infertile syndrome. To study the mechanism of sequential therapy of nourishing yin and tonifying yang prescription, and to provide the basis for the treatment of ovulatory sterility with integrated traditional Chinese and western medicine. Methods: from January 2012 to February 2015, 197 cycles of artificial indoctrination due to ovulatory disorder in reproductive medicine department of Jiangsu Provincial Hospital of traditional Chinese Medicine were analyzed retrospectively. the results showed that 197 cycles of artificial indoctrination were performed in Jiangsu Provincial Hospital of traditional Chinese Medicine. According to its treatment plan, it was divided into two groups. The control group (clomiphene group) 94 cycles, the observation group (clomiphene Ziyin Buyang recipe sequential therapy) 103 cycles. The total Gn, Gn days, intimal thickness and morphology, single follicular development, pregnancy rate and pregnancy outcome were observed. Results: the total Gn and Gn days in the observation group were significantly lower than those in the control group (P 0.05). The number of cycles of single follicular development in the observation group was larger than that in the control group, P 0.05, and the curative effect was significantly different. The pregnancy rate in the observation group was higher than that in the control group, and the curative effect was significantly different, p0.05. The cure rate, cure rate and effective rate in the observation group were significantly higher than those in the control group (P 0.05). The intimal thickness of HCG day was 8.73 鹵2.29mm, the number of type A intima was 36, the intimal thickness of observation group was 9.02 鹵2.23mm, and the number of type A intima was 39. the intimal thickness of HCG day and type A intima in observation group were higher than those in control group, but there was no significant effect of P0.05. The live infant rate and single fetus rate in the observation group were higher than those in the control group, but there was no significant difference in the curative effect. Conclusion: the sequential therapy of Ziyin Buyang recipe combined with western medicine can reduce the total amount of Gn and Gn days, thus reduce the stimulation of ovaries and promote the development of single follicles. At the same time, western medicine combined with Ziyin Buyang recipe sequential therapy can significantly improve follicular quality and pregnancy rate.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R271.14

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