中藥結(jié)合運動療法對肥胖型多囊卵巢綜合征BMI及IR指數(shù)的臨床研究
發(fā)布時間：2019-06-02 10:26
【摘要】：目的:觀察中藥結(jié)合運動綜合療法治療肥胖型PCOS的臨床療效,特別是對于該病BMI及IR指數(shù)的影響,并初步探討中藥益腎消脂方的作用機理,為該方的臨床應(yīng)用提供科學(xué)依據(jù)。方法:將90例肥胖型PCOS患者隨機分為A、B、C三組,A組30例,口服益腎消脂方并結(jié)合運動療法;B組30例,口服益腎消脂方及二甲雙胍;C組30例,口服二甲雙胍并結(jié)合運動療法。治療3個療程后,觀察3組患者的中醫(yī)臨床證候改善情況、卵巢體積變化情況、月經(jīng)周期改善情況、BMI、血清促黃體生成素(LH)、卵泡刺激素(FSH)、睪酮(T)、LH/FSH、空腹血糖(FPG)、空腹胰島素(FINS)、IR指數(shù)、總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)水平的變化情況。結(jié)果:(1)在改善中醫(yī)證候及月經(jīng)周期方面,A組療效明顯優(yōu)于B、C兩組,差異有統(tǒng)計學(xué)意義(P0.05),而B、C兩組間療效相當(dāng),差異無統(tǒng)計學(xué)意義(P0.05)。在卵巢體積的變化方面,三組均不能明顯縮小卵巢體積,差異無統(tǒng)計學(xué)意義(P0.05)。(2)在降低BMI方面,A組療效優(yōu)于B、C兩組,而C組療效優(yōu)于B組,差異有統(tǒng)計學(xué)意義(P0.05)。在降低空腹血糖和空腹胰島素水平、改善胰島素抵抗方面,A組優(yōu)于B、C兩組,而B組優(yōu)于C組,差異有統(tǒng)計學(xué)意義(P0.05)。(3)在降低LH、T值及LH/FSH方面,A組優(yōu)于B、C兩組,差異有統(tǒng)計學(xué)意義(P0.05),而B、C兩組則療效相當(dāng),差異無統(tǒng)計學(xué)意義(P0.05)。在降低TG、TC及LDL-C水平方面,A組療效優(yōu)于B、C兩組,差異有統(tǒng)計學(xué)意義(P0.05),而B、C兩組療效相當(dāng),差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:中藥結(jié)合運動療法能有效改善肥胖型PCOS患者的臨床癥狀,縮短月經(jīng)周期,恢復(fù)月經(jīng)來潮;且能減輕患者體重,有效降低BMI;降低血清LH、T、LH/FSH比值、FPG、FINS、IR指數(shù)、TC、TG、LDL-C的水平,明顯改善肥胖型PCOS患者內(nèi)分泌環(huán)境及糖脂代謝情況,從而改變肥胖型PCOS患者腎虛痰瘀的體質(zhì),臨床療效確切,值得推廣應(yīng)用。
[Abstract]:Objective: to observe the clinical efficacy of traditional Chinese medicine combined with exercise therapy in the treatment of obese PCOS, especially on the BMI and IR index of the disease, and to explore the mechanism of Yishen Xiaozhi recipe, so as to provide scientific basis for the clinical application of Yishen Xiaozhi recipe. Methods: 90 patients with obese PCOS were randomly divided into three groups: group A (n = 30), group B (n = 30) and group B (n = 30). Group C (n = 30) was treated with metformin combined with exercise therapy. After three courses of treatment, the improvement of TCM clinical syndrome, the change of ovarian volume, the improvement of menstrual cycle, and the serum LH (LH), follicular stimulating hormone (FSH), testosterone (T), LH/FSH, in the three groups were observed. Fasting blood glucose (FPG), fasting insulin (FINS), IR index, total cholesterol (TC), TG (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels. Results: (1) in improving TCM syndrome and menstrual cycle, the curative effect of group A was significantly better than that of group B. there was significant difference between group C and group C (P 0.05), but there was no significant difference between group C and group B (P 0.05). In the change of ovarian volume, all three groups could not significantly reduce the ovarian volume, the difference was not statistically significant (P 0.05). (2), the curative effect of group A was better than that of group B, and the curative effect of group C was better than that of group B, while the curative effect of group C was better than that of group B. The difference was statistically significant (P 0.05). Group A was superior to group B in reducing fasting blood glucose and fasting insulin level and improving insulin resistance, while group B was superior to group C, the difference was statistically significant (P 0.05). (3) in decreasing LH, T value and LH/FSH. Group A was better than B, C group, the difference was statistically significant (P 0.05), but B, C group was the same effect, the difference was not statistically significant (P 0.05). In reducing the level of TG,TC and LDL-C, the curative effect of group A was better than that of group B. there was significant difference between group C and group C (P 0.05), but there was no significant difference between group C and group B (P 0.05). Conclusion: traditional Chinese medicine combined with exercise therapy can effectively improve the clinical symptoms of obese PCOS patients, shorten the menstrual cycle and restore menstruation, and can reduce the body weight and BMI; of obese patients. The levels of serum LH,T,LH/FSH ratio, FPG,FINS,IR index and TC,TG,LDL-C were decreased, and the endocrine environment and glycolipid metabolism of obese PCOS patients were significantly improved, so as to change the physique of kidney deficiency, phlegm and blood stasis in obese PCOS patients. The clinical curative effect is accurate, and it is worth popularizing and applying.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R271.9
[Abstract]:Objective: to observe the clinical efficacy of traditional Chinese medicine combined with exercise therapy in the treatment of obese PCOS, especially on the BMI and IR index of the disease, and to explore the mechanism of Yishen Xiaozhi recipe, so as to provide scientific basis for the clinical application of Yishen Xiaozhi recipe. Methods: 90 patients with obese PCOS were randomly divided into three groups: group A (n = 30), group B (n = 30) and group B (n = 30). Group C (n = 30) was treated with metformin combined with exercise therapy. After three courses of treatment, the improvement of TCM clinical syndrome, the change of ovarian volume, the improvement of menstrual cycle, and the serum LH (LH), follicular stimulating hormone (FSH), testosterone (T), LH/FSH, in the three groups were observed. Fasting blood glucose (FPG), fasting insulin (FINS), IR index, total cholesterol (TC), TG (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels. Results: (1) in improving TCM syndrome and menstrual cycle, the curative effect of group A was significantly better than that of group B. there was significant difference between group C and group C (P 0.05), but there was no significant difference between group C and group B (P 0.05). In the change of ovarian volume, all three groups could not significantly reduce the ovarian volume, the difference was not statistically significant (P 0.05). (2), the curative effect of group A was better than that of group B, and the curative effect of group C was better than that of group B, while the curative effect of group C was better than that of group B. The difference was statistically significant (P 0.05). Group A was superior to group B in reducing fasting blood glucose and fasting insulin level and improving insulin resistance, while group B was superior to group C, the difference was statistically significant (P 0.05). (3) in decreasing LH, T value and LH/FSH. Group A was better than B, C group, the difference was statistically significant (P 0.05), but B, C group was the same effect, the difference was not statistically significant (P 0.05). In reducing the level of TG,TC and LDL-C, the curative effect of group A was better than that of group B. there was significant difference between group C and group C (P 0.05), but there was no significant difference between group C and group B (P 0.05). Conclusion: traditional Chinese medicine combined with exercise therapy can effectively improve the clinical symptoms of obese PCOS patients, shorten the menstrual cycle and restore menstruation, and can reduce the body weight and BMI; of obese patients. The levels of serum LH,T,LH/FSH ratio, FPG,FINS,IR index and TC,TG,LDL-C were decreased, and the endocrine environment and glycolipid metabolism of obese PCOS patients were significantly improved, so as to change the physique of kidney deficiency, phlegm and blood stasis in obese PCOS patients. The clinical curative effect is accurate, and it is worth popularizing and applying.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R271.9
【參考文獻】
相關(guān)期刊論文 前10條
1 俞靜靜;蘇潔;呂圭源;;陳皮抗心腦血管疾病相關(guān)藥理研究進展[J];中草藥;2016年17期
2 申濤;;針灸治療肥胖型多囊卵巢綜合征的臨床療效[J];深圳中西醫(yī)結(jié)合雜志;2016年06期
3 蔡賢兵;李亞;王俊玲;曹健;;電針及穴位埋線治療肥胖型多囊卵巢綜合征的臨床觀察[J];光明中醫(yī);2016年04期
4 潘文;張翌蕾;許彩鳳;;補腎化瘀方合五苓散加減治療中心性肥胖型PCOS臨床觀察[J];新中醫(yī);2016年02期
5 甘海球;唐華峰;李洪雙;蔣偉倫;;穴位埋線治療局限性神經(jīng)性皮炎臨床研究[J];中醫(yī)藥臨床雜志;2016年01期
6 顧映玉;;桂葛五苓散治療肥胖型多囊卵巢綜合征60例的臨床觀察[J];內(nèi)蒙古中醫(yī)藥;2015年11期
7 徐何方;楊頌;李莎莎;李亭亭;徐新房;李向日;;菟絲子醇提物對腎陽虛證模型大鼠免疫功能的影響[J];中藥材;2015年10期
8 陳燕;劉何s，
本文編號：2491024
本文鏈接：http://sikaile.net/zhongyixuelunwen/2491024.html
最近更新
教材專著
