【摘要】：目的:觀察復(fù)方丹紅注射液對(duì)改善血管性認(rèn)知障礙患者認(rèn)知功能損害的臨床療效。方法:本研究從2015年1月至2015年12月我院的住院及門診病人中選擇符合病例納入標(biāo)準(zhǔn)的血管性認(rèn)知障礙患者60例,并運(yùn)用計(jì)算機(jī)隨機(jī)發(fā)生器,隨機(jī)分為中藥治療組(30例)和西藥對(duì)照組(30例)。采用隨機(jī)、對(duì)照、單盲的試驗(yàn)方法,治療組予靜滴復(fù)方丹紅注射液,對(duì)照組予口服鹽酸多奈哌齊,兩組患者的基礎(chǔ)治療為抗血小板聚集、穩(wěn)定斑塊及對(duì)癥治療等,觀察兩組患者治療前后的ADAS-Cog、MMSE、Mo CA、NIHSS、ADL評(píng)分變化及中醫(yī)證候積分的變化。結(jié)果:(1)認(rèn)知功能:與治療前相比,治療組和對(duì)照組治療后的ADAS-Cog分值有所下降,MMSE及Mo CA分值有所增加,差異均有統(tǒng)計(jì)學(xué)意義(P㩳0.01),但將兩組治療后的評(píng)分進(jìn)行比較,發(fā)現(xiàn)無(wú)統(tǒng)計(jì)學(xué)意義(P㧐0.05);對(duì)治療組治療前后ADAS-Cog、MMSE及Mo CA各子項(xiàng)目分值進(jìn)一步比較,發(fā)現(xiàn)治療組ADAS-Cog子項(xiàng)目中的單詞回憶、命名、指令、單詞辨認(rèn)、回憶測(cè)驗(yàn)指令、找詞困難、語(yǔ)言理解能力、注意力等方面分值下降明顯(P0.01),在意向性練習(xí)方面分值有所下降(P0.05),而在結(jié)構(gòu)性練習(xí)、定向力、口語(yǔ)能力方面分值下降不明顯(P0.05);治療組MMSE各子項(xiàng)目中在記憶力、注意力和計(jì)算力、回憶力等方面改善明顯,差異有顯著統(tǒng)計(jì)學(xué)意義(P0.01),而在定向力、語(yǔ)言能力方面改善不明顯,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);治療組Mo CA各子項(xiàng)目中在注意力、延遲回憶方面改善明顯,差異具有顯著統(tǒng)計(jì)學(xué)意義(P0.01),在命名能力方面有一定改善(P0.05),而在視空間與執(zhí)行能力、語(yǔ)言能力、抽象力、定向力方面改善不明顯(P0.05)。(2)神經(jīng)功能缺損與日常生活能力:治療組治療后與治療前相比,NIHSS及ADL的評(píng)分均下降明顯,差異有顯著統(tǒng)計(jì)學(xué)意義(P㩳0.01),而對(duì)照組治療后與治療前相比,NIHSS評(píng)分下降不明顯(P㧐0.05),ADL評(píng)分有所下降(P㩳0.01)。(3)中醫(yī)證候:與治療前相比,治療組治療后的中醫(yī)證候積分下降明顯(P㩳0.01),對(duì)照組治療后的中醫(yī)證候積分與治療前相比差異無(wú)統(tǒng)計(jì)學(xué)意義(P㧐0.05)。結(jié)論:(1)復(fù)方丹紅注射液和鹽酸多奈哌齊均能改善血管性認(rèn)知障礙患者的認(rèn)知,延緩其病程,并且復(fù)方丹紅注射液對(duì)認(rèn)知的改善主要集中在記憶力、注意力、回憶力等方面。(2)復(fù)方丹紅注射液在改善血管性認(rèn)知障礙患者的神經(jīng)功能缺損方面優(yōu)于鹽酸多奈哌齊,但在改善日常生活能力方面療效相當(dāng);(3)復(fù)方丹紅注射液在改善血管性認(rèn)知障礙患者的中醫(yī)證候方面優(yōu)于鹽酸多奈哌齊。(4)復(fù)方丹紅注射液臨床使用療效滿意,且安全性高,無(wú)不良反應(yīng)。
[Abstract]:Objective: to observe the clinical effect of compound Danhong injection on improving cognitive impairment in patients with vascular cognitive impairment. Methods: from January 2015 to December 2015, 60 patients with vascular cognitive impairment were selected from inpatients and outpatients in our hospital, and computer random generators were used. They were randomly divided into traditional Chinese medicine treatment group (n = 30) and western medicine control group (n = 30). The treatment group was treated with compound Danhong injection intravenously, and the control group was treated with oral Donepazide hydrochloric acid. The basic treatments of the two groups were antiplatelet aggregation, stable plaque and symptomatic treatment. The changes of ADAS-Cog,MMSE,Mo CA,NIHSS,ADL score and TCM syndrome score before and after treatment were observed. Results: (1) Cognitive function: compared with before treatment, the ADAS-Cog score of the treatment group and the control group decreased, MMSE and Mo CA scores increased, the difference was statistically significant (P 鈮，

本文編號(hào)：2488597