【摘要】：目的:本課題旨在通過以益氣養(yǎng)血、活血通絡法組成的八味養(yǎng)脈湯聯(lián)合四妙勇安湯對手足綜合征的臨床療效觀察,從而探討其對手足綜合征可能的作用機制。方法:納入2016年01月到2017年01月黑龍江中醫(yī)藥大學附屬第一醫(yī)院門診和住院部符合納入標準的氣虛血瘀型手足綜合征患者60例,采用隨機對照的方法將其分成兩組,試驗組給予自擬中藥口服配合經典中藥湯劑外洗,對照組則給予維生素B6片口服配合溫水外洗,21天后評價患者治療前后手足綜合征的分級變化、疼痛程度的分級變化、生活質量(卡氏)評分變化及治療前后患者中醫(yī)證候評分的變化。結果:1.在手足綜合征分級的改善方面,試驗組總有效率為80%,對照組的總有效率為55.17%,兩組差異具有統(tǒng)計學意義(p0.05)。2.在疼痛程度的改善方面,試驗組總緩解率是86.36%,對照組的總緩解率是52.63%,差異有統(tǒng)計學意義(p0.01)。3.在生活質量(卡氏)評分的改善方面,試驗組的升高率為53.33%、穩(wěn)定率為36.67%;對照組升高率為24.14%、穩(wěn)定率為48.28%差異具有統(tǒng)計學意義(p0.05)。4.在中醫(yī)證候積分改善方面,試驗組的總有效率是86.67%,對照組總有效率是62.07%,兩組差異有統(tǒng)計學意義(p0.05)。結論:1.八味養(yǎng)脈湯聯(lián)合四妙勇安湯可以有效降低手足綜合征分級;2.八味養(yǎng)脈湯聯(lián)合四妙勇安湯可以明顯降低手足綜合征疼痛分級;3.八味養(yǎng)脈湯聯(lián)合四妙勇安湯能夠提高患者生活質量(卡氏)評分;4.八味養(yǎng)脈湯聯(lián)合四妙勇安湯能夠緩解氣虛血瘀型手足綜合征患者的癥狀,降低中醫(yī)證候積分。
[Abstract]:Objective: the purpose of this study was to observe the clinical curative effect of Bawei Yangmai decoction combined with Simiao Yong'an decoction, which was composed of Yiqi Yangxue and Huoxue Tongluo method, so as to explore the possible mechanism of hand foot syndrome. Methods: from January 2016 to January 2017, 60 patients with hand and foot syndrome of Qi deficiency and blood stasis type were randomly divided into two groups in the outpatient department and inpatient department of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. The experimental group was given oral washing of self-made traditional Chinese medicine combined with classical traditional Chinese medicine decoction, while the control group was given vitamin B6 tablets combined with warm water external washing. 21 days later, the grading changes of hand and foot syndrome and the degree of pain were evaluated. The change of quality of life (Karschner) score and the change of TCM syndrome score before and after treatment. Result: 1. In the improvement of the classification of hand and foot syndrome, the total effective rate was 80% in the experimental group and 58.17% in the control group. There was significant difference between the two groups (p0.05). In terms of improving the degree of pain, the total remission rate was 86.36% in the experimental group and 52.63% in the control group, the difference was statistically significant (p0.01). In terms of the improvement of quality of life (Karst) score, the increase rate was 53.33% and the stability rate was 36.67% in the experimental group and 24.14% in the control group, and the stability rate was 48.28%, the difference was statistically significant (p0.05). 4. In the improvement of TCM syndrome score, the total effective rate was 86.67% in the experimental group and 62.07% in the control group. There was significant difference between the two groups (p0.05). Conclusion: 1. Bawei Yangmai decoction combined with Simiao Yong an decoction can effectively reduce the grade of hand and foot syndrome. 2. Bawei Yangmai decoction combined with Simiao Yong an decoction can significantly reduce the pain grade of hand and foot syndrome. 3. Bawei Yangmai decoction combined with Simiao Yong an decoction can improve the quality of life (Karst) score of patients. 4. Bawei Yangmai decoction combined with Simiao Yong'an decoction can relieve the symptoms of hand and foot syndrome with qi deficiency and blood stasis, and reduce the syndrome score of traditional Chinese medicine.
【學位授予單位】：黑龍江中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R273

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