發(fā)布時間：2019-04-26 01:23

【摘要】：目的:觀察補腎健脾湯治療早中期慢性腎功能衰竭脾腎陽虛證的臨床療效,從而為臨床對早中期慢性腎衰脾腎陽虛證的治療提供更為有效的方法。方法:選取60例臨床慢性腎衰脾腎陽虛證患者(符合排除標準及納入標準),將其分隨機為治療組、對照組各30例,給予兩組病人西醫(yī)基礎(chǔ)治療的同時,分別給予治療組補腎健脾湯加減(日一劑,水煎2次取汁約200ml,于早晚各溫服100ml)治療及對照組以尿毒清顆粒(1包/次,沖服,4次/日)治療,均持續(xù)治療1個月后在治療前后比較兩組的中醫(yī)證候改善及血肌酐(Scr)、內(nèi)生肌酐清除率(Ccr)、血尿素氮(BUN)、血紅蛋白(Hb)、白蛋白(ALB)、尿蛋白的變化并比較二組的中醫(yī)癥候療效和臨床疾病綜合療效。結(jié)果:兩組患者年齡、病程、性別及腎功能分期分布上無顯著差異(P0.05)。治療后兩組患者中醫(yī)癥候、Scr、Ccr、BUN、Hb、ALB較治療前均有明顯好轉(zhuǎn)(P0.05)。尿蛋白于對照組治療前后無顯著改變(P0.05),僅在治療組治療后顯著下降(P0.05)。治療組中醫(yī)癥候、Scr、Ccr、BUN、尿蛋白、Hb及ALB于治療前后改善幅度顯著大于對照組(P0.05)。治療后中醫(yī)證候總積分兩組均顯著低于治療前(P0.05),且治療后中醫(yī)證候總積分治療組明顯低于對照組(P0.05)。中醫(yī)證候療效和疾病臨床綜合療效治療組均顯著優(yōu)于對照組(P0.05)。結(jié)論:補腎健脾湯對早中期慢性腎衰脾腎陽虛型患者的中醫(yī)證候療效和疾病臨床綜合療效均優(yōu)于尿毒清顆粒,可進一步臨床推廣。
[Abstract]:Objective: to observe the clinical effect of Bushen Jianpi decoction on spleen-kidney yang deficiency syndrome in early and middle stage of chronic renal failure, so as to provide a more effective method for the treatment of spleen-kidney yang deficiency syndrome in early and middle stage of chronic renal failure. Methods: 60 patients with chronic renal failure with deficiency of spleen and kidney yang were randomly divided into two groups: treatment group (n = 30) and control group (n = 30). The patients in the treatment group were treated with Bushen Jianpi decoction (one dose per day, decoction of water twice, about 200ml) and the control group were treated with Niaoduqing granule (1 pack per day, 4 times a day), while the patients in the control group were treated with 100ml at every temperature in the morning and evening, and the patients in the control group were treated with Niaoduqing granule. The improvement of TCM syndrome and creatinine (Scr), endogenous creatinine clearance rate (Ccr), blood urea nitrogen (BUN), hemoglobin (Hb), albumin (ALB), before and after treatment were compared between the two groups before and after treatment for 1 month. The changes of urinary protein were compared between the two groups. Results: there was no significant difference in age, course of disease, sex and renal function stage distribution between the two groups (P0.05). After treatment, two groups of patients with TCM symptoms, Scr,Ccr,BUN,Hb,ALB was significantly better than before treatment (P0.05). There was no significant change in urine protein before and after treatment in the control group (P0.05), only significantly decreased after treatment in the treatment group (P0.05). The improvement of Scr,Ccr,BUN, urine protein, Hb and ALB before and after treatment in the treatment group was significantly higher than that in the control group (P0.05). After treatment, the total score of TCM syndrome in the two groups was significantly lower than that before treatment (P0.05), and the total score of TCM syndrome in the treatment group after treatment was significantly lower than that in the control group (P0.05). The therapeutic effect of TCM syndrome and the clinical comprehensive curative effect of disease in the treatment group were significantly better than those in the control group (P0.05). Conclusion: Bushen Jianpi decoction is superior to Naoduqing granule in the treatment of early and middle stage chronic renal failure patients with deficiency of spleen and kidney yang in TCM syndrome and clinical comprehensive curative effect. It can be further extended in clinical practice.
【學位授予單位】：湖南中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259

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