本文關(guān)鍵詞：蚤星消腫止血散治療癤癰的臨床觀察及主要藥效學研究　出處：《湖北中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

  更多相關(guān)文章： 癤癰 蚤星消腫止血散 如意金黃散 臨床觀察 藥效學研究

【摘要】：目的:本研究主要開展蚤星消腫止血散醫(yī)療機構(gòu)制劑的研究,內(nèi)容包括蚤星消腫止血散主要藥效學研究,蚤星消腫止血散治療癤癰的臨床觀察;探索一種治療癤癰療效可靠、經(jīng)濟安全的中醫(yī)藥劑型,為其臨床推廣提供理論依據(jù)。方法與結(jié)果:1主要藥效學研究1.1消腫作用采用角叉菜膠造成大鼠足跖腫脹,觀察蚤星消腫止血散對大鼠足跖腫脹的影響。實驗結(jié)果表明:蚤星消腫止血散0.6g~1.2g·kg~(-1)能抑制角叉菜膠造成的大鼠足跖腫脹,具有消除腫脹的作用。1.2抗炎作用測量小鼠腹腔液中伊文思藍的含量,觀察蚤星消腫止血散對冰乙酸致小鼠腹腔毛細血管通透性增高的影響,從而了解其抗炎作用。實驗結(jié)果表明:蚤星消腫止血散1g·kg~(-1)~4g·kg~(-1)能抑制冰乙酸致小鼠腹腔毛細血管通透性增加,具有明顯抗炎作用。1.3抑制增生采用無菌棉球植入大鼠皮下造成肉芽腫模型,觀察蚤星消腫止血散對大鼠棉球肉芽腫的影響。實驗結(jié)果表明:蚤星消腫止血散對結(jié)締組織增生有一定的抑制作用。1.4凝血機制通過測定凝血酶原時間(PT)、活化部分凝血活酶時間(APTT)、纖維蛋白原(Fib)、凝血酶時間(TT)值,觀察蚤星消腫止血散對大鼠凝血機制的影響。實驗結(jié)果表明:蚤星消腫止血散對大鼠凝血機制無不良影響。1.5抗感染作用用金黃色葡萄球菌造成動物癤腫、瘡瘍模型,觀察蚤星消腫止血散對感染癤腫、瘡瘍大小及血清溶菌酶含量的影響,了解藥物的抗感染作用。實驗結(jié)果表明:蚤星消腫止血散對金葡菌感染致癤癰、瘡瘍大鼠,能減輕動物中毒癥狀、明顯減小癤腫直徑、促進破潰愈合、提高感染動物血清溶菌酶含量,具有提高機體免疫功能、增強抗感染能力的作用。2臨床研究通過對120例患者的臨床觀察表明:蚤星消腫止血散治療癤、癰(郁火毒結(jié)型,濕熱毒蘊型)具有很好的臨床療效,總有效率達90%以上,明顯優(yōu)于對照組。其在降低血白細胞、中性粒細胞百分比及療程方面,與對照組相比無明顯差別,而在改善臨床癥狀和體征方面則明顯優(yōu)于對照組,能明顯改善癤、癰患者肌膚紅腫、q.熱、疼痛等癥狀。蚤星消腫止血散安全有效,無不良反應(yīng),值得臨床推廣。結(jié)論:此次研究表明蚤星消腫止血散經(jīng)過科學合理的制備,穩(wěn)定安全,無毒副作用,具有清熱解毒、消腫止血的功效,能夠明顯改善癤癰患者的臨床癥狀。因此,開發(fā)蚤星消腫止血散醫(yī)療機構(gòu)制劑對治療癤癰有著重要意義。
[Abstract]:Objective: this study mainly carried out the research on the preparation of xunxingxiaozongzhixue powder, including the main pharmacodynamics study of xunxingxiaozongzhixue powder, and the clinical observation of the treatment of furuncle carbuncle with xxxingzongzhixue powder; To explore a safe and economical Chinese medicine dosage form for the treatment of furuncle and carbuncle. Methods and results the main pharmacodynamics of 1. 1. Effect of carrageenin on the swelling of rat feet and metatarpae induced by carrageenin. Methods and results: 1.The swelling effect was caused by carrageenin in rats. To observe the effect of Xiaozong Zhixue Powder (XXXXZZXS) on the swelling of foot and metatarsus in rats. The experimental results showed that the XXXXZH (0.6 g / kg) could inhibit the paw swelling induced by carrageenan in rats. Anti-inflammatory effect of anti-swelling. 1.2. Measure the content of Evans blue in mouse peritoneal fluid, observe the effect of XXXZXS on the increase of capillaries permeability induced by acetic acid in mice. The experimental results showed that Daphnia xinxiaozongzhixue powder (1 g 路kg~(-1)~4g 路kg ~ (-1)) could inhibit the increase of capillaries permeability induced by acetic acid in mice. Has obvious anti-inflammatory effect. 1.3 inhibition proliferation of aseptic cotton balls implanted into the subcutaneous rat granuloma model. To observe the effect of xuoxing xiaozong Zhixue powder on cotton ball granuloma in rats. The experimental results showed that xxxxxxiaozongzhixue powder could inhibit connective tissue proliferation to a certain extent .1.4 coagulation mechanism was determined by measuring prothrombin time (P < 0.05). PTT. Activated partial thromboplastin time (APTT), fibrinogen (Fib), thrombin time (TT). To observe the effect of Xiaozong Zhixue Powder (XXXXXS) on the coagulation mechanism of rats. The experimental results showed that XXXZZH had no adverse effect on the coagulation mechanism of rats .1.5 Antiinfective effect of Staphylococcus aureus caused animal furuncle. To observe the effect of XXXZZXS on infected furuncle, size of ulcer and serum lysozyme content. To understand the anti-infective effect of drugs. The experimental results showed that: flea Xingxiaozong Zhixue Powder on the furuncle carbuncle caused by Staphylococcus aureus infection, sore rats, can alleviate the symptoms of animal poisoning, significantly reduce the diameter of furuncle, promote healing. Increase the content of serum lysozyme in infected animals, improve the immune function of the body, enhance the ability of anti-infection. 2 Clinical study on 120 cases of patients showed that: flea Xingxiaozong Zhixuesan treatment of furuncle. Carbuncle (stagnation of fire toxin type, damp-heat toxin accumulation type) has a very good clinical efficacy, the total effective rate of more than 90%, significantly better than the control group, in reducing the percentage of white blood cells, neutrophils and course of treatment. Compared with the control group, there is no significant difference, but in improving clinical symptoms and signs is significantly better than the control group, can significantly improve the furuncle, carbuncle patients skin swelling Q.heat. Pain and other symptoms. Daphnia xingxiaozongzhixue powder is safe and effective, no adverse reactions, worthy of clinical promotion. Conclusion: this study shows that Daphnia xingxiaozongzhixue powder is scientifically and reasonably prepared, stable and safe, without toxic and side effects. It can obviously improve the clinical symptoms of patients with furuncle carbuncle. Therefore, it is of great significance for the treatment of furuncle carbuncle to develop the medical organization preparation of Xiaxing Xiazong Zhixue powder for treating furuncle and carbuncle.
【學位授予單位】：湖北中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R26

【相似文獻】

相關(guān)期刊論文 前10條

1 吳秀成;王靜;;愈潰止血散治療消化性潰瘍并出血38例[J];中國民族民間醫(yī)藥雜志;2007年02期

2 吳秀成;王靜;;愈潰止血散治療消化性潰瘍并出血38例[J];中國民間療法;2007年04期

3 李春杰,王虎崗;介紹一種止血散[J];新中醫(yī);1985年08期

4 焦源;;椿歸止血散治療痔出血250例[J];湖北中醫(yī)雜志;1985年06期

5 李春杰;;止血散的配制及應(yīng)用[J];云南中醫(yī)雜志;1986年02期

6 史蒼柏,秦克力,韓秀榮,董桂芝,黃萍;中藥止血散治療特發(fā)性血小板減少性紫癜的臨床和實驗研究[J];中醫(yī)藥信息;1999年01期

7 張建新,魏美芳;自擬止血散治療胃十二指腸潰瘍出血108例療效分析[J];現(xiàn)代中西醫(yī)結(jié)合雜志;2000年09期

8 劉衛(wèi)萍,李明辰,劉逢芹;愈瘍止血散的制備及臨床應(yīng)用[J];時珍國醫(yī)國藥;2002年10期

9 張修廷;張洋;;勃薊止血散治痔瘡術(shù)后出血[J];河南中醫(yī);1984年03期

10 ;椿歸止血散治療痔出血250例[J];中國農(nóng)村醫(yī)學;1986年02期

相關(guān)會議論文 前4條

1 喬象松;喬毅皓;馬懷昌;郭紅;胡林飛;;止血散對急性上消化道出血臨床應(yīng)用的體會[A];中國中西醫(yī)結(jié)合學會第十四次全國消化系統(tǒng)疾病學術(shù)研討會論文匯編[C];2002年

2 葉漢華;封培昌;;止血散治療上消化道出血30例療效觀察[A];中國中西醫(yī)結(jié)合學會第十二次全國消化系統(tǒng)疾病學術(shù)研討會論文匯編[C];2000年

3 金慶文;;中西醫(yī)結(jié)合治療急性上消化道出血68例[A];2000年全國危重病急救醫(yī)學學術(shù)會議論文集[C];2000年

4 徐基偉;胡春陽;張小元;李淑霞;史樹勛;;止血散加生肌玉紅膏治療直腸潰瘍21例臨床觀察[A];2011年甘肅省中醫(yī)藥學會學術(shù)年會論文集[C];2011年

相關(guān)重要報紙文章 前1條

1 張世筠;治療出血可用藕[N];健康時報;2006年

相關(guān)碩士學位論文 前3條

1 張煥蘭;生肌止血散內(nèi)鏡下噴灑治療上消化道出血療效及藥理實驗[D];廣州中醫(yī)藥大學;2016年

2 周憶烈;蚤星消腫止血散治療癤癰的臨床觀察及主要藥效學研究[D];湖北中醫(yī)藥大學;2016年

3 周苗;蚤星消腫止血散醫(yī)院制劑的藥學研究[D];湖北中醫(yī)藥大學;2015年

，

本文編號：1428680