藥用植物是人類獲取臨床藥物的主要來源之一,其所含活性成分的研究是尋找先導(dǎo)化合物、開發(fā)新藥的有效途徑。如抗瘧藥物青蒿素即是從菊科蒿屬植物黃花蒿中分離獲取。然而,從基質(zhì)復(fù)雜的藥用植物中直接萃取分離目標成分具有挑戰(zhàn)性。為此,人們先后將硅膠、氧化鋁、大孔吸附樹脂和活性炭等多孔材料應(yīng)用于藥用植物中目標成分的萃取分離。由于材料結(jié)構(gòu)和表面性質(zhì)等方面的原因,這些材料的分離選擇性均受到不同程度的限制。因此,尋找和研制高選擇性和較大吸附容量的多孔材料對于高效制備藥用植物中的目標成分具有重要意義。金屬-有機骨架材料（MOFs）是一類由金屬離子或離子簇與有機功能配體自組裝形成的多孔功能性材料,具有較大比表面積、良好熱穩(wěn)定性和化學(xué)穩(wěn)定性、結(jié)構(gòu)和孔可調(diào)等優(yōu)點,目前在氣體儲存、催化、傳感和分離等領(lǐng)域得到了廣泛的研究和應(yīng)用。此外,MOFs半有機骨架、規(guī)則有序的孔結(jié)構(gòu)和活潑的金屬配位點使其在選擇性吸附萃取方面具有良好的應(yīng)用潛力,其應(yīng)用已涵蓋從簡單基質(zhì)中的有機小分子到復(fù)雜基質(zhì)中的多肽、蛋白質(zhì)、染料等生物大分子。鑒于MOFs在復(fù)雜樣品中具有良好的選擇性吸附萃取能力,將MOFs用于選擇性萃取藥用植物中的活性成分將是一個很有意... 

【文章來源】：天津大學(xué)天津市 211工程院校 985工程院校 教育部直屬院校

【文章頁數(shù)】：92 頁

【學(xué)位級別】：碩士

【文章目錄】：
摘要
abstract
Chapter 1 Literature review
    1.1 Research progress of Caragana jubata （C. jubata）
        1.1.1 Chemical components
        1.1.2 Pharmacological activities
        1.1.3 Separation methods research
    1.2 Metal-Organic Frameworks
        1.2.1 Properties of MOFs
        1.2.2 Synthesis methods
        1.2.3 Applications
    1.3 Research topic
Chapter 2 MOFs screening and identification of main components of DCM extract
    2.1 Introduction
    2.2 Experimental section
        2.2.1 Chemicals and reagents
        2.2.2 Instruments
        2.2.3 MOFs screening
        2.2.4 Preparation of DCM extract of C. jubata
        2.2.5 Separation and identification
    2.3 Results and discussions
        2.3.1 MOFs screening
        2.3.2 Structure identification
Chapter 3 Selective extraction and adsorption mechanism of ZIF-8
    3.1 Experimental section
        3.1.1 Chemicals and reagents
        3.1.2 Instruments
        3.1.3 Synthesis and characterization of ZIF-8
        3.1.4 Extraction and condition optimization of ZIF-8 for compound 1
        3.1.5 Recovery test of compound 1
        3.1.6 Adsorption mechanism study
    3.2 Results and discussions
        3.2.1 Characterization of ZIF-8
        3.2.2 Selective extraction of compound 1
        3.2.3 Optimization of adsorption/desorption conditions
        3.2.4 Results of recovery test
        3.2.5 Adsorption mechanism
    3.3 Extraction of active components on other MOFs
Chapter 4 Pharmacological activities of the selectively adsorbed compound
    4.1 Experimental section
        4.1.1 Chemicals and reagents
        4.1.2 Instruments
    4.2 Antioxidant activity analysis
        4.2.1 Scavenging activity against DPPH free radical
        4.2.2 Assay of ferric reducing/antioxidant power （FRAP）
        4.2.3 Inhibitory effect on lipid peroxidation induced by Fe2+/ascorbate
    4.3 Antiplatelet aggregation activity in vitro
    4.4 Antiproliferative activity assay
    4.5 Results and discussions
        4.5.1 Antioxidant activity analysis
        4.5.2 Antiplatelet aggregation activity in vitro
        4.5.3 Antiproliferative activity assay
Chapter 5 Conclusions and prospects
    5.1 Conclusions
    5.2 Prospects
References
Appendices
Notes on publications and participation in scientific research
Acknowledgements


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