研究振源膠囊對辛伐他汀及其活性代謝產(chǎn)物辛伐他汀酸在大鼠體內(nèi)的藥動(dòng)學(xué)影響,為臨床兩藥聯(lián)合應(yīng)用提供一定的理論依據(jù)。將24只雄性Wistar大鼠隨機(jī)分成對照組與實(shí)驗(yàn)組,每組12只,對照組連續(xù)灌胃3‰羧甲基纖維素鈉15天,實(shí)驗(yàn)組連續(xù)灌胃振源膠囊混懸液15天。兩組大鼠于16日清晨均灌胃給予等量辛伐他汀5.3mg/kg。給藥后不同時(shí)間點(diǎn)進(jìn)行眼內(nèi)眥靜脈叢采血,離心即得血漿樣品。采用HPLC-MS/MS法測定辛伐他汀及辛伐他汀酸的血藥濃度。應(yīng)用DAS 2.1.1軟件擬合藥動(dòng)學(xué)參數(shù), SPSS 25.0軟件分析統(tǒng)計(jì)學(xué)差異。結(jié)果發(fā)現(xiàn),聯(lián)用振源膠囊后,辛伐他汀酸及辛伐他汀的藥動(dòng)學(xué)參數(shù)AUC0–24與Cmax均顯著性減少（P<0.05）。振源膠囊可能對CYP3A4酶有一定促進(jìn)作用,可減少辛伐他汀及其代謝產(chǎn)物在大鼠體內(nèi)的含量。 

【文章來源】：Journal of Chinese Pharmaceutical Sciences. 2020,29(07)

【文章頁數(shù)】：10 頁

【文章目錄】：
1. Introduction
2. Experimental
    2.1. Medicines and chemicals
    2.2. Equipment and analysis conditions
    2.3. Preparation of standard solutions and quality control samples
    2.4. Preparation of intragastrical solutions
    2.5. Preparation of plasma sample
3. Method validation
    3.1. Linearity of calibration curves and LLOQ
        3.1.1. Accuracy and precision
        3.1.2. Recovery and matrix effect
        3.1.3. Stability
    3.2. Animal experiment
    3.3. Statistics
4. Results and discussion
    4.1. Method validation
        4.1.1. Specificity
        4.1.2. Linearity of calibration curve and LLOQ
        4.1.3. Precision and accuracy
        4.1.4. Recovery and matrix effect
        4.1.5. Stability
        4.1.6. Pharmacokinetic study
5. Discussion
6. Conclusions


【參考文獻(xiàn)】：
期刊論文
[1]辛伐他汀對大鼠骨質(zhì)疏松性骨折愈合的影響[J]. 田發(fā)明,張柳,駱陽,宋亞琪,楊方.  中國藥學(xué)雜志. 2012(21)
[2]Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action[J]. Yong CHENG Li-hong SHEN Jun-tian ZHANG Institute of Materia Medica,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100050,China.  Acta Pharmacologica Sinica. 2005(02)



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