【摘要】：目的:探討辛伐他汀保護(hù)高脂飲食致腎臟損傷的新機(jī)制。方法:雌性SD大鼠隨機(jī)分為標(biāo)準(zhǔn)飲食組、高脂飲食組及辛伐他汀治療組,高脂飲食組和辛伐他汀治療組先予高脂飲食20周,后者在高脂飲食的同時(shí)予辛伐他汀~([10 mg/(kg·d)])灌胃治療8周。分析大鼠血脂和腎臟的病理學(xué)變化、腎臟中脂聯(lián)素、脂聯(lián)素受體R1,R2,AMP依賴的蛋白激酶(AMPK),過氧化物酶體增殖物激活受體α(PPARα)、葡萄糖調(diào)節(jié)蛋白78(GRP78)和轉(zhuǎn)錄因子GADD153(CHOP)的表達(dá)。結(jié)果:高脂飲食組大鼠體質(zhì)和血脂水平明顯增高,脂聯(lián)素及其受體表達(dá)明顯下調(diào),AMPKα磷酸化降低,PPARα表達(dá)降低,GRP78和CHOP基因表達(dá)水平均明顯上調(diào)。辛伐他汀治療組上述指標(biāo)均出現(xiàn)明顯改善。結(jié)論:辛伐他汀可能通過升高腎臟脂聯(lián)素及其受體的表達(dá),減少內(nèi)質(zhì)網(wǎng)應(yīng)激來改善高脂誘導(dǎo)的大鼠腎臟損傷。
[Abstract]:Objective: to investigate the new mechanism of simvastatin in protecting kidney injury induced by high fat diet. Methods: female SD rats were randomly divided into standard diet group, high-fat diet group and simvastatin treatment group, high-fat diet group and simvastatin treatment group were given high-fat diet for 20 weeks, the latter was given simvastatin ~ (10 mg/ (kg 路d) intragastrically for 8 weeks. The pathological changes of blood lipid and kidney, the expression of adiponectin, adiponectin receptor R1, R2, (AMPK), peroxisome proliferator activated receptor 偽 (PPAR 偽), glucose regulated protein 78 (GRP78) and transcription factor GADD153 (CHOP) in kidney were analyzed. Results: in the high fat diet group, the levels of physique and blood lipid were significantly increased, the expression of adiponectin and its receptor was significantly down-regulated, the phosphorylation of AMPK 偽 was decreased, the expression of PAPAR 偽 was decreased, and the expression of GRP78 and CHOP genes was significantly up-regulated. The above indexes were significantly improved in simvastatin treatment group. Conclusion: simvastatin may improve renal injury induced by high fat by increasing the expression of adiponectin and its receptor in kidney and reducing endoplasmic reticulum stress.
【作者單位】： 安徽醫(yī)科大學(xué)生物化學(xué)教研室;安徽醫(yī)科大學(xué)第一附屬醫(yī)院內(nèi)分泌科;
【基金】：國(guó)家中醫(yī)臨床研究基地業(yè)務(wù)建設(shè)專項(xiàng)課題(編號(hào):JDZX2015129)
【分類號(hào)】：R965

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