【摘要】：目的:自制伏立康唑磺丁基醚-β-環(huán)糊精包合物與注射用伏立康唑(VFEND~汶)大鼠體內藥動學對比研究。方法:以VFEND~汶為對照,Wistar大鼠為受試動物,采用超高效液相-飛行時間質譜(U-HPLC/Q-TOF-MS)監(jiān)測伏立康唑的血藥濃度,計算藥動學參數,對自制藥與對照藥的各藥動參數進行獨立樣本雙側t檢驗。結果:自制藥和對照藥大鼠體內伏立康唑的消除半衰期(t1/2)分別為(2.099±0.202)h和(2.142±0.163)h,藥物濃度-時間曲線下面積(AUC0-12)分別為(23.247±1.264)μg·h·mL~(-1)和(22.748±1.568)μg·h·mL~(-1)。結論:自制藥與對照藥的大鼠體內藥動學行為相似,各藥動學參數相近。
[Abstract]:Aim: to compare the pharmacokinetics of Voliconazole sulfonbutyl ether-尾-cyclodextrin inclusion complex and Voliconazole (VFEND~ Wen) rats for injection. Methods: VFEND~ and Wistar rats were used as control and Wistar rats as subjects. The blood concentration of Voliconazole was monitored by ultra-high performance liquid phase-time-of-flight mass spectrometry (U-HPLC/Q-TOF-MS). The pharmacokinetics parameters were calculated and the pharmacokinetics parameters of Vriconazole were tested by bilateral t-test of independent samples. Results: the elimination half-life (T1 鈮，

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