【摘要】：目的:了解我院抗菌藥物所致藥品不良反應(yīng)(ADR)發(fā)生的特點(diǎn),為臨床合理使用抗菌藥物提供參考。方法:對(duì)我院2011-2013年上報(bào)的159例抗菌藥物致ADR報(bào)告,按患者的性別及年齡、科室分布、給藥途徑、涉及藥品種類、聯(lián)合用藥情況、ADR累及器官/系統(tǒng)及臨床表現(xiàn)等進(jìn)行回顧性統(tǒng)計(jì)、分析。結(jié)果:0~10歲患兒和60歲老年患者ADR發(fā)生率最高,分別占23.90%、34.59%;抗菌藥物靜脈給藥途徑ADR發(fā)生率最高,占86.16%;頭孢菌素類藥物發(fā)生的ADR最多,占30.82%;聯(lián)合用藥致ADR高達(dá)31.45%;抗菌藥物所致ADR主要累及皮膚及其附件損害,占32.08%。結(jié)論:醫(yī)療機(jī)構(gòu)應(yīng)加強(qiáng)抗菌藥物ADR的報(bào)告和監(jiān)測(cè)工作,確保患者用藥安全。
[Abstract]:Objective: to investigate the characteristics of adverse drug reactions (ADR) caused by antimicrobial agents in our hospital and to provide reference for rational use of antimicrobial agents. Methods: 159 cases of ADR caused by antimicrobial agents were reported in our hospital from 2011 to 2013. According to the sex and age of the patients, the distribution of the department, the way of administration, the kinds of drugs involved, and the situation of combined use of drugs, the results were as follows: 1. ADR involved organs / systems and clinical manifestations were retrospectively analyzed. Results: the incidence of ADR was the highest in children aged 10 years old and 60 years old, accounting for 23.900.59%, the incidence of ADR in intravenous administration of antibiotics was the highest (86.16%), the incidence of ADR in cephalosporins was the highest (30.82%). ADR caused by combined use was 31.455.The ADR caused by antimicrobial agents mainly involved skin and its adnexal damage, accounting for 32.08. Conclusion: medical institutions should strengthen the reporting and monitoring of antimicrobial ADR to ensure the safety of drug use.
【作者單位】： 重慶市中醫(yī)院呼吸內(nèi)科;
【分類號(hào)】：R95

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