【摘要】：為了了解氫氧化鈣緩釋腸溶膠囊的給藥特性及應(yīng)用,本文采用體外模擬法考察了氫氧化鈣緩釋腸溶膠囊的給藥動(dòng)力學(xué),并對(duì)其解酒抗醉作用進(jìn)行評(píng)價(jià)。結(jié)果表明,氫氧化鈣的代謝受其釋放速度控制,負(fù)載量在3.2~5.5 mmol/g范圍,其溶解度穩(wěn)定在10 mg/100m L左右,釋放半衰期在13~45 min,并隨負(fù)載量的增大而縮短,緩釋為分層釋放,各層符合零級(jí)釋放模型;家兔急毒試驗(yàn)表明氫氧化鈣緩釋腸溶膠囊安全無(wú)毒,解酒抗醉結(jié)果為解酒組和抗醉組的醉睡時(shí)間分別為163 min和125 min,比模型組的259 min明顯縮短,氫氧化鈣緩釋腸溶膠囊具有較強(qiáng)的解酒抗醉能力。
[Abstract]:In order to understand the characteristics and application of calcium hydroxide sustained-release enteric-soluble capsules, the pharmacokinetics of calcium hydroxide sustained-release enteric-coated capsules was investigated by in vitro simulation method, and the antiintoxication effect of calcium hydroxide sustained release enteric capsules was evaluated. The results showed that the metabolism of calcium hydroxide was controlled by the release rate of calcium hydroxide, the loading amount was in the range of 3.2g / 5.5 mmol/g, the solubility of calcium hydroxide was about 10 mg/100m / L, and the half life of calcium hydroxide was 1345 min, and shortened with the increase of loading amount. The slow release is layered release, each layer accords with zero order release model. The acute toxicity test of rabbits showed that calcium hydroxide sustained-release enteric-coated capsule was safe and non-toxic. The antiintoxication time of antiintoxication group and anti-intoxication group were 163 min and 125 min, respectively, which were significantly shorter than that of the model group (259 min). Calcium hydroxide sustained-release enteric capsule has strong antiintoxication ability.
【作者單位】： 廣西大學(xué)化學(xué)化工學(xué)院廣西石化資源加工及過(guò)程強(qiáng)化技術(shù)重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(21166004)
【分類(lèi)號(hào)】：R96

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