【摘要】：目的:建立一種快速,準(zhǔn)確,自動(dòng)化的光纖傳感μSI-LOV(順序注射-閥上實(shí)驗(yàn)室)測(cè)定纈沙坦膠囊含量的新方法。方法:建立光纖傳感μSI-LOV系統(tǒng),在丙酮溶劑中氯冉酸與纈沙坦發(fā)生專屬荷移,屏蔽輔料干擾。通過系統(tǒng)編程,優(yōu)化實(shí)驗(yàn)條件,自動(dòng)化測(cè)定纈沙坦膠囊的含量。結(jié)果:優(yōu)選條件:吸入順序依次為丙酮、纈沙坦、氯冉酸、纈沙坦及丙酮,纈沙坦前后吸入體積比為3∶2,纈沙坦總吸入體積為200μL,氯冉酸吸入體積為20μL,纈沙坦的荷移吸光度與質(zhì)量濃度在0.064~0.32 mg·m L-1范圍內(nèi)的線性關(guān)系為:A=1.497C+0.302,r=0.999 8,精密度RSD為0.337%,回收率96.2%~102.9%,平均每粒含量為81.10 mg,占標(biāo)示量101.27%,與HPLC法比較無顯著差異,P0.05。結(jié)論:本方法通過制定個(gè)性化編程,實(shí)現(xiàn)自動(dòng)化快速分析,重復(fù)性好,試劑用量少,分析效率高,成本低,方法可靠。
[Abstract]:Objective: to establish a rapid, accurate and automatic optical fiber sensing 渭 SI-LOV method for the determination of valsartan capsules. Methods: the optical fiber sensing 渭 SI-LOV system was established, and the exclusive charge transfer between chloranilic acid and valsartan was observed in acetone solvent, and the interference of auxiliary materials was shielded. The content of valsartan capsule was determined automatically by systematic programming and optimization of experimental conditions. Results: the order of inhalation was acetone, valsartan, chloranilic acid, valsartan and acetone. The volume ratio of valsartan to valsartan was 3: 2, the total volume of valsartan was 200 渭 L, the volume of chloranilic acid was 20 渭 L. The linear relationship between the charge transfer absorbance of valsartan and the mass concentration of valsartan in the range of 0.064 ~ 0.32 mg 路mL ~ (-1) was as follows: An 1.497C 0.302C 0.302C ~ (0.302L) 0.999 ~ 8, the precision RSD = 0.337. the recovery rate was 96.2n ~ 102.9%. The average grain content per seed was 81.10 mg, and 101.27%, which had no significant difference compared with HPLC method (P 0.05). Conclusion: this method has the advantages of rapid automatic analysis, good reproducibility, low reagent dosage, high efficiency, low cost and reliability.
【作者單位】： 泰州市興化市第五人民醫(yī)院;泰州安琪婦產(chǎn)醫(yī)院;中國人民解放軍69220部隊(duì)醫(yī)院;喀什地區(qū)第一人民醫(yī)院;
【基金】：國家自然科學(xué)基金(編號(hào):81260486) 新疆維吾爾自治區(qū)自然科學(xué)基金(編號(hào):201233150)
【分類號(hào)】：R927.2

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