【摘要】：目的改進(jìn)地奧司明的半合成路線。方法橙皮苷與三氯化鋁絡(luò)合,溶于甲醇中,以吡啶為除酸劑,碘為脫氫劑,生成地奧司明絡(luò)合物,再經(jīng)磷酸脫鋁離子,即得到地奧司明。結(jié)果以橙皮苷計(jì),地奧司明的收率為96.4%,純度為93.7%,熔點(diǎn)為278.6℃,在254、266、345 nm處有最大吸收,與對照品在薄層色譜上的Rf值和顯色情況一致。結(jié)論該合成路線中的吡啶用量減少80%,反應(yīng)體系為溶液型,條件溫和,后處理簡單,收率較高,具有工業(yè)化生產(chǎn)能力。
[Abstract]:Objective to improve the semi-synthetic route of Diosmin. Methods Diosmin complex was formed by complexing hesperidin with aluminum trichloride, dissolved in methanol, pyridine as acid remover, iodine as dehydrogenant, and then dealuminized by phosphoric acid. Results based on hesperidin, the yield of Diosmin was 96.4, the purity was 93.7, the melting point was 278.6 鈩，

本文編號：2383865