【摘要】：目的:制備溴新斯的明多囊脂質(zhì)體(NB-MVL),并對(duì)其體外藥物釋放行為進(jìn)行考察。方法:采用復(fù)乳法制備載藥多囊脂質(zhì)體,并用單因素試驗(yàn)優(yōu)化處方,以動(dòng)態(tài)透析技術(shù)與f2相似因子評(píng)價(jià)法對(duì)NB-MVL與溴新斯的明在體外不同釋放介質(zhì)中的釋放行為進(jìn)行研究,計(jì)算其藥物釋放度與相似因子。結(jié)果:NB-MVL的包封率受投料比、藥物濃度等因素影響;NB-MVL在不同的釋放介質(zhì)中所獲得的釋放模型均符合Weibull模型,同時(shí)與溴新斯的明溶液在不同釋放介質(zhì)中所得累積釋放曲線間的相似因子小于50。結(jié)論:本試驗(yàn)制備所得NB-MVL包封率較高,且體外藥物釋放行為與溴新斯的明存在顯著性差異,表現(xiàn)出良好的緩釋作用。
[Abstract]:Aim: to prepare bromoneostigmine polycystic liposomes (NB-MVL) and investigate their drug release behavior in vitro. Methods: drug loaded polycystic liposomes were prepared by double emulsion method. The release behavior of NB-MVL and bromoxtigmine in different release media in vitro was studied by dynamic dialysis technique and f2 similarity factor evaluation method, and single factor test was used to optimize the formulation. The drug release and similar factors were calculated. Results: the entrapment efficiency of NB-MVL was influenced by the ratio of feed and the concentration of drug. The release models obtained by NB-MVL in different release media all accord with the Weibull model, and the similarity factor between the cumulative release curve and bromoxamine solution in different release media is less than 50. Conclusion: the entrapment efficiency of NB-MVL prepared in this study was high, and the drug release behavior in vitro was significantly different from that of brominostigmine, showing a good sustained release effect.
【作者單位】： 重慶醫(yī)科大學(xué)藥物高校工程研究中心;重慶醫(yī)科大學(xué)附屬第二醫(yī)院藥學(xué)部;
【分類號(hào)】：R943;R96

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本文編號(hào)：2372548