發(fā)布時(shí)間：2018-11-01 16:17

【摘要】：為減少一些非甾體抗炎藥(NSAIDs)長(zhǎng)期服用產(chǎn)生的嚴(yán)重胃腸道副作用,故設(shè)計(jì)合成了兩個(gè)NSAIDs布洛芬與鹽酸美金剛通過(guò)氨基酸的偶聯(lián)的化合物。以布洛芬為原料,與草酰氯反應(yīng)生成酰氯,再與氨基酸反應(yīng)生成酰胺,最后與鹽酸美金剛縮合,得到新型結(jié)構(gòu)的目標(biāo)化合物N-[1-(3,5-二甲基-三環(huán)[3.2.1.0~(3.6)]癸烷-1-氨甲酰基)-甲基]-2-(4-異丁基苯基)丙酰胺(Ⅱ1),N-[1-(3,5-二甲基-三環(huán)[3.2.1.0~(3,6)]癸烷-1-氨甲酰基-乙基]-2-(4-(異丁基苯基)丙酰胺(Ⅱ2),其結(jié)構(gòu)經(jīng)核磁共振(1 H NMR)、紅外光譜儀(IR)和高分辨質(zhì)譜儀(HR-MS)確證。
[Abstract]:In order to reduce the severe gastrointestinal side effects caused by long-term administration of some non-steroidal anti-inflammatory drugs (NSAIDs), two NSAIDs ibuprofen coupling compounds with methadine hydrochloride through amino acids were designed and synthesized. Ibuprofen was used as raw material to react with oxaloyl chloride to form acyl chloride, and then to react with amino acid to form amide. N- [1- (3- (3-) -dimethyl-tricyclo [3.2.1.0 ~ (3.6)] decane-1-carbamyl) -methyl] -2- (4-isobutyl phenyl) propionamide (鈪，

本文編號(hào)：2304445