【摘要】：目的:研究鹽酸哌甲酯(methylphenidate hydrochloride,MPH)速溶膜(oral fast dissolving films,OFDF)在大鼠體內(nèi)的藥動(dòng)學(xué)。方法:12只大鼠隨機(jī)分為MPH灌胃組(40 mg·kg-1)、MPH-OFDF舌下給藥組(40 mg·kg~(-1))2組,每組6只。麻醉后分別給藥并在不同時(shí)間點(diǎn)取血。采用高效液相色譜法測(cè)定大鼠血漿中MPH濃度,用DAS 2.1軟件計(jì)算藥動(dòng)學(xué)參數(shù),并用SPSS 20.0統(tǒng)計(jì)軟件進(jìn)行獨(dú)立性t檢驗(yàn)分析。結(jié)果:MPH灌胃組t1/2為(1.81±0.81)h,AUC0~4h為(3.49±0.42)mg·L~(-1)·h,tmax和Cmax分別為(0.58±0.13)h和(2.44±0.36)mg·L~(-1)。MPH-OFDF舌下給藥組t1/2為(1.35±0.53)h,AUC0~4h為(15.36±0.53)mg·L~(-1)·h,tmax和Cmax分別為(0.33±0.13)h和(9.49±0.70)mg·L~(-1)。MPH-OFDF舌下組與MPH灌胃組相比,t1/2縮短,但無(wú)顯著性差異,而tmax顯著縮短(P0.01),AUC0~4h和Cmax顯著增大(P0.01)。結(jié)論:與MPH口服給藥相比,MPH-OFDF舌下給藥吸收快,生物利用度有所提高。
[Abstract]:Aim: to study the pharmacokinetics of methylphenidate hydrochloride (methylphenidate hydrochloride,MPH) instant membrane (oral fast dissolving films,OFDF in rats. Methods: twelve rats were randomly divided into MPH group (40 mg kg-1) and sublingual MPH-OFDF group (40 mg kg~ (-1) with 6 rats in each group. After anesthesia, the drug was given separately and blood was taken at different time points. The concentration of MPH in rat plasma was determined by HPLC, the pharmacokinetic parameters were calculated by DAS 2.1 software, and the independent t test was performed by SPSS 20.0 statistical software. 緇撴灉:MPH鐏岃儍緇則1/2涓，

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