輔助分子伴侶對HSP90構象功能的調節(jié)及其在腫瘤中的作用
發(fā)布時間：2018-09-10 14:03
【摘要】：熱休克蛋白90(heat shock protein 90,HSP90)作為一種重要的分子伴侶,參與調控眾多原癌客戶蛋白的折疊、裝配和成熟,在腫瘤的發(fā)生發(fā)展中發(fā)揮重要作用。三磷酸腺苷(adenosine triphosphate,ATP)的結合和二磷酸腺苷(adenosine diphosphate,ADP)/ATP的交換是驅動HSP90分子伴侶構象循環(huán)的關鍵要素。其中一些輔助分子伴侶協(xié)助HSP90的構象循環(huán)過程,參與腫瘤惡性進展。本文對一些常見的輔助分子伴侶,如Hop、CDC37、p23、AHA1和PP5等的結構、功能及其協(xié)助HSP90參與腫瘤發(fā)生發(fā)展的過程進行綜述。
[Abstract]:As an important molecular chaperone, heat shock protein 90 (HSP90) is involved in the regulation of the folding, assembly and maturation of many proto-cancer client proteins, and plays an important role in the development of cancer. The binding of adenosine triphosphate (adenosine triphosphate,ATP) and the exchange of adenosine diphosphate (adenosine diphosphate,ADP) / ATP are the key factors driving the conformational cycle of HSP90 molecular chaperones. Some of the accessory molecular chaperones assist in the conformational cycle of HSP90 and participate in the malignant progression of the tumor. In this paper, the structures, functions of some common comolecular chaperones, such as Hop,CDC37,p23,AHA1 and PP5, and the process of assisting HSP90 in tumorigenesis and development are reviewed.
【作者單位】： 中國醫(yī)學科學院北京協(xié)和醫(yī)學院藥物研究所天然藥物活性物質與功能國家重點實驗室;
【基金】：國家自然科學基金資助項目(81573466)
【分類號】：R96
[Abstract]:As an important molecular chaperone, heat shock protein 90 (HSP90) is involved in the regulation of the folding, assembly and maturation of many proto-cancer client proteins, and plays an important role in the development of cancer. The binding of adenosine triphosphate (adenosine triphosphate,ATP) and the exchange of adenosine diphosphate (adenosine diphosphate,ADP) / ATP are the key factors driving the conformational cycle of HSP90 molecular chaperones. Some of the accessory molecular chaperones assist in the conformational cycle of HSP90 and participate in the malignant progression of the tumor. In this paper, the structures, functions of some common comolecular chaperones, such as Hop,CDC37,p23,AHA1 and PP5, and the process of assisting HSP90 in tumorigenesis and development are reviewed.
【作者單位】： 中國醫(yī)學科學院北京協(xié)和醫(yī)學院藥物研究所天然藥物活性物質與功能國家重點實驗室;
【基金】：國家自然科學基金資助項目(81573466)
【分類號】：R96
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相關期刊論文 前1條
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【共引文獻】
相關期刊論文 前4條
1 薛妮娜;金晶;陳曉光;;輔助分子伴侶對HSP90構象功能的調節(jié)及其在腫瘤中的作用[J];藥學學報;2017年07期
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