【摘要】：目的考察聚乙二醇維生素E琥珀酸酯(TPGS)修飾的姜黃素脂質(zhì)體的藥代動(dòng)力學(xué)和在體腸吸收。方法大鼠灌胃給藥,高效液相色譜法測(cè)定各時(shí)間點(diǎn)的血藥濃度,應(yīng)用DAS軟件處理數(shù)據(jù);采用大鼠在體單向灌流模型,考察TPGS修飾的姜黃素脂質(zhì)體在不同腸段的吸收情況。結(jié)果 TPGS修飾的姜黃素脂質(zhì)體的血藥濃度-時(shí)間曲線下面積(AUC),最大血藥濃度(Cmax)分別為游離藥物的2.13、2.61倍;其十二指腸、空腸、回腸、結(jié)腸各腸段的吸收速率常數(shù)(Ka)相對(duì)于游離藥物分別提高了0.84、1.77、1.48、4.99倍,有效滲透率(Peff)相對(duì)于游離藥物分別提高了1.56、2.06、2.82、7.17倍。結(jié)論 TPGS修飾的姜黃素脂質(zhì)體有良好的促吸收效果,并能提高姜黃素的生物利用度。
[Abstract]:Objective to investigate the pharmacokinetics and in vivo absorption of curcumin liposomes modified with polyethylene glycol vitamin E succinate (TPGS). Methods Rats were given intragastric administration of curcumin liposomes at different time points by high performance liquid chromatography (HPLC). The data were processed by DAS software and the absorption of curcumin liposomes modified by TPGS in different intestinal segments was investigated by unilateral perfusion model in vivo. Results the area of TPGS modified curcumin liposome was 2.13 ~ 2.61 times higher than that of free curcumin liposome, and the area under the curve of concentration and time of (AUC), was 2.13 ~ 2.61 times of that of free drug, respectively, and its duodenum, jejunum, ileum, jejunum and ileum were also increased. Compared with free drugs, the absorption rate constant (Ka) of colon and the effective permeability (Peff) of colon were increased by 0.84 ~ 1.77 ~ 1.484.99 times and 1.56 ~ 2.206 ~ 2.82 ~ 7.17 times higher than those of free drugs, respectively. Conclusion TPGS modified curcumin liposomes has a good absorption effect and can improve the bioavailability of curcumin.
【作者單位】： 重慶醫(yī)科大學(xué)藥物高校工程研究中心;
【基金】：重慶市教育委員會(huì)首批高等學(xué)校優(yōu)秀人才資助項(xiàng)目(KJ120321)
【分類號(hào)】：R965

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 羅見(jiàn)春;何丹;尹華峰;趙德璋;張景R，

本文編號(hào)：2199073