【摘要】：目的研究合用雷公藤多苷片和阿托伐他汀之后,雷公藤多苷片對阿托伐他汀在大鼠體內藥動學的影響。方法 12只雄性SD大鼠,隨機分為A、B兩組,其中A組為單獨給藥組,灌胃給藥阿托伐他汀2 mg·kg~(-1),B組為聯(lián)合用藥組,灌胃給予雷公藤多苷片和阿托伐他汀,其給藥劑量都為2 mg·kg~(-1)。在不同時間點取血,采用HPLC測定阿托伐他汀的血藥濃度,計算并比較阿托伐他汀的藥動學參數(shù)。結果與單獨給藥組相比,藥物聯(lián)用組阿托伐他汀的藥動學參數(shù)發(fā)生了明顯的變化,阿托伐他汀的最大血藥濃度由(4.77±0.64)mg·L~(-1)上升到(7.79±0.61)mg·L~(-1),血漿曲線下面積由(12.82±3.50)mg·h·L~(-1)增加到(27.39±5.76)mg·h·L~(-1),同時達峰時間由(0.25±0.03)h延長到(0.52±0.07)h,半衰期由(2.39±0.19)h延長到(5.09±1.35)h,平均駐留時間由(2.93±0.23)h延至(4.36±0.44)h,說明阿托伐他汀的代謝可能受到了抑制。結論雷公藤多苷片和阿托伐他汀聯(lián)用之后,會對阿托伐他汀的藥動學產生一定程度的影響,導致達峰時間、半衰期延長,最大血藥濃度增大,可能對阿托伐他汀鈣的代謝具有抑制作用。本實驗對雷公藤多苷片和阿托伐他汀聯(lián)合用藥具有一定的指導作用。
[Abstract]:Objective to study the effect of tripterygium wilfordii polyglycoside tablets and Atto vastatin tablets on the pharmacokinetics of Atto vastatin in rats. Methods Twelve male Sprague-Dawley rats were randomly divided into two groups: group A was administered alone, group B was given Atto vastatin 2 mg kg ~ (-1) by gavage, Tripterygium wilfordii polyglycoside tablets and Atto vastatin were given orally, the dosage was 2 mg kg ~ (-1). The serum concentrations of Atto vastatin were measured by HPLC at different time points, and the pharmacokinetic parameters of Atto vastatin were calculated and compared. Results the pharmacokinetic parameters of Atto vastatin in the combined drug group were significantly different from those in the single administration group. 闃挎墭浼愪粬姹，

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